阿托伐他汀联合氨氯地平治疗高血压病合并冠心病的疗效观察

Observation on Efficacy of Amlodipine Combined with Atorvastatin Calcium Tablets in Treatment of Hypertension Complicated with Coronary Heart Disease

目的:探讨阿托伐他汀联合氨氯地平治疗高血压病合并冠心病的效果。方法:选取2014年6月—2016年6月麻城市人民医院收治的高血压病合并冠心病患者70例作为研究对象。根据随机数字表法分为观察组和对照组各35例。对照组患者给予氨氯地平治疗,观察组患者给予氨氯地平联合阿托伐他汀治疗。观察2组患者的临床疗效。结果:观察组患者的总有效率为94.29(33/35),明显高于对照组患者的68.57(24/35),差异有统计学意义(P<0.05);治疗后,观察组患者的收缩压、舒张压、总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平显著低于对照组,高密度脂蛋白胆固醇水平明显高于对照组,差异均有统计学意义(P<0.05)。结论:阿托伐他汀联合氨氯地平治疗高血压病合并冠心病的临床效果较好。

OBJECTIVE： To probe into the effects of amlodipine combined with Atorvastatin calcium tablets in treatment of hypertension complicated with coronary heart disease. METHODS： 70 patients admitted into Macheng People＇s Hospital from Jun. 2014 to Jun. 2016 were selected to be divided into observation group and control group via the random number table,with 35 cases in each. The control group were treated with amlodipine,while the observation group were additionally given atorvastatin. The clinical efficacy of two groups were observed. RESULTS： The total effective rate of observation group was 94. 29%（ 33 /35）,significantly higher than that of control group [68. 57%（ 24 /35） ],with statistically significant difference（ P〈0. 05）. After treatment,the systolic pressure,diastolic pressure,total cholesterol,triacylglycerol and low density lipoprotein cholesterol level in observation group were significantly lower than those of control group,yet high density lipoprotein cholesterol levels was significantly higher than that of control group,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The clinical effects of amlodipine combined with Atorvastatin calcium tablets in treatment of hypertension complicated with coronary heart disease is relatively remarkable.