非布司他与小剂量苯溴马隆治疗高尿酸血症的对比研究

Comparative Study on Febuxostat and Low Doses of Benzbromarone in Treatemt of Hyperuricaemia

目的:探讨非布司他与小剂量苯溴马隆治疗高尿酸血症的治疗效果。方法:选取武警浙江总队嘉兴医院收治的高尿酸血症患者120例作为研究对象。所有患者以随机数字表法分为观察组和对照组各60例。观察组患者给予非布司他80 mg,1日1次;对照组患者给予苯溴马隆25 mg,1日1次。观察2组患者的各项指标水平、疗效及不良反应发生情况。结果:治疗后,观察组患者血尿酸水平显著低于对照组,差异有统计学意义(P<0.05);2组患者血白细胞计数、肌酐、丙氨酸氨基转移酶水平的差异无统计学意义(P>0.05);观察组患者的总有效率为96.67%(58/60),对照组患者的总有效率为90.00%(54/60),差异有统计学意义(P<0.05);观察组患者不良反应发生率为6.67%(4/60),明显低于对照组的15.00%(9/60),差异有统计学意义(P<0.05)。结论:与苯溴马隆相比,非布司他治疗高尿酸血症的疗效更确切,能有效减低尿酸水平,安全性更高。

OBJECTIVE： To probe into the treatment effects of febuxostat and low doses of benzbromarone in treatemt of hyperuricaemia. METHODS： 120 patients with hyperuricemia admitted into Jiaxing Hospital of Zhejiang Armed Police Corps were selected to be divided into observation group and control group via the random number table,with 60 cases in each.The observation group were given febuxostat 80 mg,once a day; and the control group were treated with benzbromarone25 mg,once a day. Various indicators,efficacy and adverse drug reactions of two groups were observed. RESULTS： After treatment,the uric acid of observation group was significantly lower than that of control group,with statistically significant difference（ P〈0. 05）. There was no statistically significant difference between two groups in leukocyte,creatinine,ALT（ P〈0. 05）. The total effective rate in observation group was 96. 67%（ 58/60）,and in control group was 90. 00%（ 54/60）,with statistically significant difference（ P〈0. 05）. The incidence of adverse drug reactions in observation group was 6. 67%（ 4/60）,significantly lower than that of control group [15. 00%（ 9/60） ],with statistical significance（ P〈0. 05）.CONCLUSIONS： Compared with benzbromarone,the efficacy of febuxostat in treatment of hyperuricemia is definite,which can reduce the uric acid level with high safety.