冠状动脉钙化与血浆脂蛋白a的相关性研究

目的脂蛋白a与冠状动脉钙化的相关性及其在临床中的应用价值。方法选取136例行冠脉造影检查患者，分为A组（PCI），B组（冠状动脉狭窄50％至70％之间），C组（冠状动脉狭窄50％以下），并根据脂蛋白a水平（300mg／L）每组分为2个亚组，测定冠状动脉钙化积分，并随访一年复查冠脉造影、钙化积分、脂蛋白a，进行统计比较分析。结果随访前后各组之间脂蛋白a、钙化积分均有差异（P〈0.05），A2、B2、C2组之间脂蛋白a和钙化积分正相关。随访前后亚组之间冠脉粥样硬化进展有差异（P〈0.05）。结论脂蛋白a较高的患者，冠状动脉钙化较严重，冠状动脉粥样硬化进展过程较快，支架内再狭窄发生率较高。

Objective The correlation between lipoprotein （a）and coronary artery calcification and its application in clinical value. Methods Select 136 patients with coronary angiography examination,divided into group A（PCI）,group B（Coronary artery stenosis 50% to 70%） ,group C（Coronary artery stenosis less than 50%） ,And according to the level of LP （a） （300 rag/L） in each group was divided into two subgroups,determine coronary artery calcium score. Follow-up of one year, reexamine coronary angiograpby examina tion,coronary artery calcium score,lipoprotein （a）, made statistical comparative analysis. Results Lipoprotein （a） and calcification scores were different between the each groups before and after one year（P〈0.05）. Lipoprotein （a） and the calcification score are positively correlated in group A2,B2~C2o There were differences in the progression of coronary atherosclerosis between the subgroups before and after one year（P〈0. 05）. Conclusion Lipoprotein （a）in patients with a high, severe coronary artery calcification and coronary atherosclerosis progress faster, with a greater incidence of stent restenosis.