小儿急性中枢神经系统病毒感染近期不良预后因素探究

目的分析小儿急性中枢神经系统病毒感染近期不良预后因素。方法选取在本院儿科接受住院治疗的急性中枢神经系统病毒感染患儿299例作为研究对象，对可能的不良预后影响因素进行单因素分析并通过二分类Logistic回归分析不良预后的独立危险因素。结果人院前病程、发热持续时间、CSF白细胞数、血钙含量、意识障碍、多次惊厥发作、惊厥持续状态、脑膜刺激征、肌力异常、EEG是否正常、颅脑CT／MRI是否正常是患儿的不良预后因素；意识障碍、多次惊厥发作、EEG重度异常、颅脑CT／MRI异常是影响急性中枢神经系统病毒感染患儿近期不良预后的独立危险因素。结论临床上应早期识别急性中枢神经系统病毒感染的不良预后因素并及早干预治疗以改善患儿的预后。

Objective Analysis of recent adverse prognostic factors of acute central nervous system virus infection in children. Methods 299 cases of children with acute central nervous system infection in our hospital were selected as the research object, Univariate analysis of possible adverse prognostic factors and the independent risk factors for adverse outcomes were analyzed by two Logistic regression analysis. Results Pre admission duration of fever, continuous time, CSF white blood cell number, calcium content,disturbance of consciousness, multiple seizures, CSE, meningeal irritation, muscle abnormalities, whether the normal EEG, brain CT/MRI is normal or not is with poor prognosis factors. Disturbance of consciousness, multiple seizures, severe abnormalities of EEG, and CT/ MRI abnormalities are independent risk factors for adverse prognosis in children with acute central nervous system infection. Conclusion Early intervention to improve the prognosis of children with adverse prognostic factors in the clinical treatment of children.