盐酸戊乙奎醚联合血液灌流治疗急性重度有机磷农药中毒临床分析

目的探讨分析盐酸戊乙奎醚联合血液灌流治疗急性重度有机磷农药中毒的具体方法及疗效，以期能有效增加患者治愈几率及其预后生存能力。方法选取我院2011年1月至2016年2月近五年来收治的102例急性重度有机磷农药中毒患者，将其随机分成对照组和联合组，每组51例。两组患者均给予呼吸机维持其呼吸、缓解脑水肿、脱水降低颅内压等常规治疗急性重度有机磷农药中毒措施。对照组给予肌注盐酸戊乙奎醚进行治疗，在对照组基础上联合组给予联合血液灌流进行治疗。观察记录两组患者临床治愈几率、胆碱酯酶活性复原时长、住院天数、昏迷时长、住院费用、死亡率及呼吸衰竭、中间综合征等并发症发生几率，并对其进行比较分析。结果联合组临床治愈几率、死亡率及呼吸衰竭、中间综合征等并发症发生几率均显著优于对照组（P〈0.05）。联合组胆碱酯酶活性复原时长、住院天数、昏迷时长均显著少于对照组（P〈0.05）。对照组住院费用为（1．75±0．31）万元；联合组住院费用为（2．42±1．03）万元。联合组住院费用显著高于对照组（P〈0.05）。结论盐酸戊乙奎醚联合血液灌流治疗急性重度有机磷农药中毒能有效增加其治愈几率，临床效果显著，有效改善患者病情，有效增加其机体耐受能力，显著提高其生活质量，缩短治疗时间，减轻病痛带来的危害，减少昏迷时长及死亡率，降低呼吸衰竭、中间综合征等并发症发生几率，提高患者远期生存能力。值得推广于临床应用。

Objective To investigate and analyze the flow in the treatment of acute severe organophosphorus pesticide poisoning the concrete method and the effect of penehyclidine hydrochloride combined with blood perfusion, in order to effectively increase the cure rate and survival ability. Methods 102 cases of acute severe organophosphorus pesticide poisoning in our hospital from January 2011 to February 2016 in our hospital were randomly divided into the control group and the combined group, 51 cases in each group. Two groups of patients were given the breathing machine to maintain their breathing, to alleviate brain edema, dehydration and other conventional treatment of acute severe organophosphorus pesticide poisoning. The control group received intramuscular injection of penehyclidine hydrochloride treatment in the control group based on joint group received combined with blood perfusion treatment. Record two groups of patients with clinical cure probability and cholinesterase recovery time, hospitalization days and coma is observed when the length and cost of hospitalization, mortality and respiratory failure, intermediate syndrome of complication incidence and carries on the comparative analysis. Results the incidence of clinical cure rate, mortality and respiratory failure, intermediate syndrome and other complications were significantly higher than those in the control group （P〈0.05）. The length of time, length of stay, duration of coma were significantly less than that of control group （P〈0.05）. The cost of hospitalization in the control group was （1.75-[-0.31）, and the combined group was （2.42± 1.03）. The hospitalization expense of the combined group was significantly higher than that of the control group （P〈0.05）. Conclusion penehyclidine hydrochloride combined with blood perfusion flow treatment of acute severe organophosphorus pesticide poisoning can effectively increase the probability of cure, clinical effect significantly, effectively improve the patient＇s condition, effectively increase the body resistance, significantly improve the quality of life, shorten the treatment time, light pain of harm reduction, reduce the coma and mortality, reduce the incidence of respiratory failure, intermediate syndrome and other complications, improve the ability of long term survival in patients. It is worth promoting in clinical application.