棕榈酸帕利哌酮注射液治疗急性精神分裂症的疗效及糖脂代谢的影响

目的分析棕榈酸帕利哌酮注射液治疗急性精神分裂症的疗效及对糖脂代谢的影响情况。方法42例患者随机分为对照组和实验组，对照组口服利培酮片，实验组进行榈酸帕利哌酮肌肉注射，观察记录患者用药后4周、8周的疗效及随访6个月、12个月对糖脂代谢的影响情况。结果治疗4周和8周后，实验组的总有效率分别为52．38％、71．43％显著高于对照组的38．1％、47．62％，有统计学意义（P〈0.05）。随访调查期间，治疗6个月和治疗12个月两组GLU、2hPBG、TG、TC比较，实验组与对照组之间无差异显著，无统计学意义（P〉0.05），两组与治疗前比较无统计学差异（P〉0．05）。结论棕榈酸帕利哌酮注射液治疗急性精神分裂症疗效显著，且对体内糖脂代谢影响较小，值得在临床上推广。

Objective To analyze the palmitic acid paliperidone injection treatment of acute mental split in the clinical efficacy and influence on glucose and lipid metabolism. Methods 42 patients were randomly assigned to the control group and the experimental group, the control group oral risperidone tablets, the experimental group were palmitic acid paliperidone intramuscular injection, observe and record the patients medication after 4 weeks, 8 weeks the curative effect and followed up for 6 months, 12 months effect on glucose and lipid metabolism. Results after 4 weeks and 8 weeks of treatment, the experimental group total effectiveness is 54.2%, 71.43% was significantly higher than that of 38.1% in the control group, 47.62%, statistically significant （P〈0.05）. With During his visit to the investigation and treatment for 6 months and treatment 12 month two groups of Glu 2hpbg, TG, TC, the experimental group and the control group had no significant difference, no statistical significance （P〉0.05）, two groups before and after treatment no significant difference （P〉0.05）. Conclusion palmitie acid Palli eefoperazone injection treatment of acute mental division sickness curative effect is remarkable and has little effect on glucose and lipid metabolism in vivo, it is worth in clinical promotion.