天津地区Graves病流行病学调查

Epidemiological survey of Graves' disease in Tianjin area

目的 调查天津地区Graves病患病率及其影响因素。方法 自 1997年 4月～ 1999年12月 ,采用分层整群抽样方法 ,对天津地区 6个区 (县 )内居住 1年以上、年龄 6周岁以上的社区居民进行Graves病流行病学抽样调查 ,共 315 30例。由甲状腺病专家、流行病学专家和技术人员组成调查组 ,可疑对象经专家组复查后 ,行甲状腺激素和抗体测定及B超等检查确诊。结果 共发现Graves病患者 89例 ,总患病率 0 2 82 % ,其中男 2 6例 (0 16 6 % ) ,女 6 3例 (0 397% ) ,男女性别构成比为 1∶2 4。不同性别间患病率差异有显著性 (P <0 0 0 1) ,女性明显高于男性。Graves病患病高峰年龄 ,男为 5 0～年龄段 ,女为 30～年龄段。这个年龄段患病率与其他年龄段比较 ,差异有极显著性 (P <0 0 0 1)。有、无家族史之间的患病率差异有显著性 (P <0 0 0 1)。随食盐中含碘量增加 ,尿中碘排量显著增加 ,甲状腺肿大率明显下降 ,但甲状腺功能亢进发病率出现上升趋势。

Objective To study the incidence of Graves' disease and associated factors Methods From 1997 4 to 1999 12, by using cluster and stratified sampling, total of 31 530 people aged 6 years and over were surveyed epidemiologically for Graves' disease in five districts and one county of Tianjin area where the study subjects had been resided for at least one year The researching team consisted of endocrinologists, epidemiologists and technicians and was divided into three branches, they served as investigators, professional experts and technicians, respectively The serum thyroid hormones, thyroid antibodies, iodine in table salt, urine iodine and B US were examined for the suspected cases, the final diagnoses were concluded by the professional experts Results Eighty nine patients with Graves' disease were confirmed, 26(0 166%) of them were males and 63(0 397%) of them were females, the total incidence was 0 282% The incidence significantly associated with sex (female higher than male, P <0 001), age (50～60 group for male and 30～40 group for female higher than others, P <0 001) and family history (the patients with vs without family history, P <0 001) The survey showed an ascending trend of incidence of Graves' disease, along with decreasing of goiter rate and increasing of iodine contents in table salt and in urine. Further research work should be pursued Conclusion This study may provide some theoretical basis for prevention and treatment of Graves' disease