妊娠期妇女口服叶酸预防新生儿神经管畸形的合理剂量探讨

On Appropriate Oral Dose of Folic Acid During Pregnancy to Prevent Neural Tube Defects

目的:通过对妊娠期补充叶酸剂量及结果的讨论,促进妊娠期妇女叶酸补充剂的合理使用。方法:使用文献综述的方法,对叶酸的药理作用、临床应用、剂量及临床结局等问题进行论述,并比较国内市场上市的叶酸片。结果与结论:妊娠期妇女在补充叶酸时,临床应按照妊娠期妇女的具体情况合理选用不同剂量的叶酸,无高危因素的妊娠期妇女推荐为0.4 mg/d,若有生育神经管畸形婴儿高风险推荐补充剂量为4mg/d至5mg/d。

Objective： Discussion on folic acid dose and results in pregnancy, to promote the rational use of folic acid supplements in pregnant women. Method.＂ The pharmacological effects of folic acid and clinical application, doses and clinical outcomes and other issues are discussed through the literature reviews.And the two specifications of folic acid tablets＇ production in the domestic market are compared. Result and Conclusions： The dose of daily folic acid supplements in pregnant women in different situations should be carefully chosen.Different doses of folic acid should be selected reasonable in accordance with the specific situation of women in pregnancy. 0.4 mg/d folic acid is recommended for no risk of NTDs pregnancy women, 4mg/d to 5mg/d folic acid is recommended for high risk pregnancy women.