川芎嗪注射液联合硫酸镁和酚妥拉明治疗妊娠高血压综合征的临床研究

Clinical study on Ligustrazine Hydrochloride Injection combined with magnesium sulfate and phentolamine in treatment of pregnancy induced hypertension syndrome

目的探讨川芎嗪注射液联合硫酸镁和酚妥拉明治疗妊娠高血压综合征的临床疗效。方法选取2014年7月—2015年7月滨州医学院烟台附属医院收治的妊娠高血压综合征患者86例,按治疗方案的差别分为对照组和治疗组,每组各43例。对照组静脉滴注硫酸镁注射液,30 m L加入到5%葡萄糖溶液500 m L中,1次/d;并静脉滴注甲磺酸酚妥拉明注射液,20 mg加入到5%葡萄糖溶液250 m L中,1次/d。治疗组在对照组基础上静脉滴注盐酸川芎嗪注射液,120 mg加入到5%葡萄糖溶液250 m L中,1次/d。两组患者均治疗10 d。观察两组的临床疗效,比较两组的血细胞比容(HCT)、平均动脉压(MAP)、24 h尿蛋白(Upro)、一氧化氮(NO)、超氧化物歧化酶(SOD)、内皮素-1(ET-1)、丙二醛(MDA)和并发症。结果治疗后,对照组和治疗组的总有效率分别为81.40%、95.35%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组HCT、MAP和24 h Upro明显低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组NO和SOD水平显著升高,而ET-1和MDA水平明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗组胎盘早剥、产后出血、胎儿窘迫、宫缩乏力和新生儿窒息发生率明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论川芎嗪注射液联合硫酸镁和酚妥拉明治疗妊娠高血压综合征具有较好的临床疗效,可改善血管内皮功能,降低氧自由基水平,减轻尿蛋白,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Ligustrazine Hydrochloride Injection combined with magnesium sulfate and phentolamine in treatment of pregnancy induced hypertension syndrome. Methods Patients （86 cases） with pregnancy induced hypertension syndrome in Yantai Affiliated Hospital of Binzhou Medical University from July 2014 to July 2015 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were iv administered with Magnesium Sulfate Injection, 30 mL added into 5% glucose solution 500 mL, once daily. And Patients in the control group were also iv administered with Phentoiamine Mesilate Injection, 20 mg added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were iv administered with Ligustrazine Hydrochloride Injection on the basis of the control group, 120 mg added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and HCT, MAP, 24 h Upro, NO, SOD, ET-1, MDA, and complication in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.40% and 95.35%, respectively, and there was difference between two groups （P 〈 0.05）. Atier treatment, HCT, MAP, and 24 h Upro in the treatment group were significantly lower than those in the control group, and there was difference between two groups （P 〈 0.05）. After treatment, the levels of NO and SOD in two groups were significantly increased, but the levels of ET-1 and MDA in two groups were significantly decreased, and the difference was statistically significant in the same group （P 〈 0.05）. And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups （P 〈 0.05）. The incidence rates of placental abruption, postpartum bleeding, fetal distress, uterineinertia, and neonatal asphyxia in the treatment group were significantly lower than those in the control group, and there was difference between two groups （P 〈 0.05）. Conclusion Ligustrazine Hydrochloride Injection combined with magnesium sulfate and phentolamine has clinical curative effect in treatment of pregnancy induced hypertension syndrome, can improve vascular endothelial function, reduce the level of oxygen free radical, and decrease the urine protein, which has a certain clinical application value.