更年宁心颗粒联合希明婷片治疗更年期综合征的疗效观察

Clinical observation of Gengnian Ningxin Granules combined with Ximingting Tablets in treatment of menopausal syndrome

目的探究更年宁心颗粒联合希明婷治疗女性更年期综合征的临床疗效。方法选取2015年3月—2015年12月在大连市西岗区妇幼保健计划生育服务中心接受治疗的更年期综合征患者156例,随机分成对照组和治疗组,每组各78例。对照组患者口服希明婷片,1片/次,3次/d。治疗组在对照组的基础上口服更年宁心颗粒,1包/次,2次/d。两组患者连续治疗4个月。观察两组患者的临床疗效,比较两组治疗前后的汉密尔顿抑郁量表(HAMD)、Kupperma和更年期生活质量(MRS)评分,以及雌二醇(E2)、促卵泡激素(FSH)和黄体生成素(LH)水平,同时观察两组患者不良反应情况。结果治疗后,对照组和治疗组的总有效率分别为87.2%和96.2%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组HAMD、Kupperma和MRS评分均低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组E2水平高于对照组,且FSH和LH水平低于对照组,但两组比较差异无统计学意义。治疗过程中对照组和治疗组的不良反应发生率分别为15.4%和11.5%,两组不良反应发生率比较差异有统计学意义(P<0.05)。结论采用更年宁心颗粒联合希明婷治疗女性更年期综合征,可改善患者生活质量、调节患者体内的激素水平,具有一定的临床推广应用价值。

Objective To explore the clinical effect of Gengnian Ningxin Granules combined with Ximingting Tablets in treatment of menopausal syndrome. Methods Patients （156 cases） with menopausal syndrome in Women Health Care, Maternal and Child Health Care Family Planning Service Center of Xigang District of Dalian from March 2015 to December 2015 were randomly divided into control and treatment groups, and each group had 78 cases. Patients in the control group were po administered with Ximingting Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Gengnian Ningxin Granules on the basis of the control group, 1 bag/time, twice daily. Patients in two groups were treated for 4 months. After treatment, the efficacy was evaluated, and the scores of HAMD, Kupperma, and MRS, and the levels of E2, FSH, and LH in two groups were compared, at the same time, adverse reaction in two groups were observed. Results After treatment, the clinical efficacy in the control and treatment groups were 87.2% and 96.2%, respectively, and there were differences between two groups （P 〈 0.05）. After treatment, the scores of HAMD, Kupperma, and MRS in treatment group were significantly lower than those in the control group, with significant difference between two groups （P 〈 0.05）. After treatment, E2 level in the treatment group was higher than that in the control group, FSH and LH levels were lower than those in the control group, however, there were no differences between two groups. During the treatment, adverse reaction rate in the control and treatment groups were 15.4% and 11.5%, respectively, and there were differences between two groups （P 〈 0.05）. Conclusion Gengnian Ningxin Granules combined with Ximingting Tablets has a significant clinical effect in treatment of menopausal syndrome, and can improve the quality of life, and regulate the hormone levels, which has a certain clinical application value.