支气管肺发育不良定义和命名的演变与治疗进展

The evolvement of definition and nomenclature in bronchopulmonary dysplasia and advances in its treatment

支气管肺发育不良（ bronchopulmonary dysplasia,BPD）又称慢性肺疾病（ chronic lung disease,CLD）,是早产儿常见的呼吸系统疾病；1967年由Northway等首次报道并命名,具有独特的病因、病理及临床特征。 Northway等报道的BPD又称“旧”BPD或“经典型”BPD。由于产前糖皮质激素和出生后外源性肺表面活性物质的应用,以及保护性通气策略的实施,显著地改变了早产儿呼吸系统疾病的表现形式和预后。 Northway描述的严重 BPD已很少见,更为常见的是轻型 BPD （又称为“新”BPD）。自从1967年首次提出BPD以来,BPD的定义或命名一直存在争议。本文系统介绍了BPD定义的历史变迁和治疗进展。

Bronchopulmonary dysplasia （ BPD） ,also called chronic lung disease （ CLD） ,is a com-mon respiratory disease of premature infants. It was first reported and named by Northway et al, carrying unique etiology,pathology and clinical features. BPD reported by Northway is referred as old or classic BPD. Manifestations and prognosis of premature infants with respiratory diseases have been improved significantly after evolutional changes by applying glucocorticoid and exogenous surfactant,as well as protective ventilator protocols after birth. Nowadays,incidents of severe BPD described by Northway are extremely low,whereas mild BPD,also called ‘new’ BPD,is much more common. Definition and nomenclature of BPD have been controversial since first being brought out in 1967. This article was focused on the definition and nomenclature and current advances in BPD treatment.