极低与超低出生体重儿动脉导管未闭管理与支气管肺发育不良发生的关系

The relationship of patent ductus arteriosus management and the development of bronchopulmonary dysplasia in very and extremely low birth weight infants

早产儿支气管肺发育不良（ bronchopulmonary dysplasia,BPD）是早产儿特别是极低和超低出生体重儿常见的并发症之一。 BPD在其发生发展过程中受到多种因素的影响,其中动脉导管未闭（ patent ductus arteriosus,PDA）及其临床管理,特别是PDA不同的治疗方案和治疗时机的选择对BPD发生的影响受到广泛关注。本文总结了早产儿PDA管理与BPD发生关系的研究进展,并在此基础上提出可能有利于降低早产儿BPD发生率的PDA管理建议。

Bronchopulmonary dysplasia（ BPD） is one of the common complications in premature in-fants,especially those with very and extremely low birth weight. Among all the related factors of BPD,the role of patent ductus arteriosus（ PDA） and especially its management with the different approaches and tim-ing of interventions have received widespread attention. Research progresses of the relationship between patent ductus arteriosus management and the development of BPD were summarized . On the basis of that,the sug-gestions focusing on lowering the incidence of BPD in very /extremely low birth weight infants are recom-mended.