环丙沙星注射液不良反应影响因素的非条件logistic回归分析

Non-conditional logistic regression analysis on the influencing factors of the adverse reaction of ciprofloxacin injection

目的：观察环丙沙星注射液的不良反应类型及探讨不良反应发生的影响因素。方法以2013年1月至2015年12月就诊于我院并应用环丙沙星注射液的病例为研究对象，采用回顾性分析的方法记录病例中患者的性别、年龄等临床资料，统计研究病例中环丙沙星注射液不良反应发生特点及发生率，采用非条件logistic回归分析法探讨影响环丙沙星注射液发生不良反应的可能因素。结果共纳入研究病例1689例，其中由环丙沙星导致的不良反应共53例，发生率为3.14%。环丙沙星的不良反应主要发生于消化系统、神经系统及皮肤附件，发生率约占所有不良反应的90.57%。卡方检验单因素分析结果显示，年龄、过敏史、是否联合用药、疗程及给药剂量均可能为环丙沙星注射液发生不良反应的危险因素；非条件logistic回归分析的结果表明，年龄、过敏史、是否联合用药、治疗疗程及给药剂量均为影响环丙沙星发生不良反应的独立危险因素（P〈0.05）。结论环丙沙星注射液不良反应发生率低，但不良反应可发生于多个器官系统，以消化系统、神经系统、皮肤与附件系统发生率为高；非条件logistic回归显示年龄、过敏史、联合应用其他抗菌药、给药剂量等均为影响环丙沙星注射液发生不良反应的独立危险因素。临床应用环丙沙星注射液要详细了解患者病史及相关资料，遇到高危患者要密切关注可能发生的不良反应。

Objective To observe the adverse reaction types of ciprofloxacin injection and to explore the influencing fac-tors on the incidence of adverse reactions. Methods The cases of ciprofloxacin injection were studied in our hospital from Janu-ary 2013 to December 2015, and retrospective analysis was used to record the gender, age and other clinical data of the patients. Characteristics and incidence rate of adverse reaction of ciprofloxacin injection were statistically studied, and non-conditional lo-gistic regression analysis was used to explore the possible factors influencing the adverse reaction of ciprofloxacin injection. Re-sults A total of 1 689 cases were included in the study, and among them, 53 cases of adverse reactions were caused by cipro-floxacin, with the incidence rate 3. 14%. The adverse reactions mainly occurred in the digestive system, nervous system and skin appendages, accounting for 90. 57% of all the adverse reactions. Chi square test single factor analysis showed that age, history of allergies, the combination of medication, course of treatment and dosage of the drug may be the risk factors for adverse reaction of ciprofloxacin injection, and the results of non conditional logistic regression analysis showed that age, history of allergy, com-bined medication, treatment duration and dosage were independent risk factors for adverse reaction of ciprofloxacin （P〈 0. 05）. Conclusion The incidence rate of adverse reaction of ciprofloxacin injection is low, but the adverse reaction can occur in multi-ple organ systems, and the incidence is high in digestive system, nervous system, skin and accessory system. Non conditional lo-gistic regression showed that age, history of allergy, combined use of other antimicrobial agents, and drug administration were all independent risk factors for adverse reaction of ciprofloxacin injection. Clinical application of ciprofloxacin injection needs a de-tailed understanding of the patient’s history and related information, and patients with high-risk should pay close attention to the possible adverse reactions.