过敏原检测在抗结核药物引起的肝损害患者中的临床意义

Clinical signi?cance of allergy testing in patients with Anti-tuberculosis Drug-induced liver injury

目的:探讨过敏原检测在抗结核治疗发生药物性肝损伤(DILI)的患者中的临床意义。方法:483例发生肝损伤的结核患者进行血清过敏原检测,同时检测450例未发生肝损伤的结核患者血清过敏原作为对照。结果:483例肝损患者血清过敏原检测阳性率为62.5%(302/483),而未发生肝损组为21.3%(96/450),差异有统计学意义(P<0.01)。分别比较吸入性及食入性过敏原阳性率,肝损组均明显高于未发生肝损组(P<0.01)。结论:抗结核治疗发生DILI的患者具有较高的血清过敏原检测阳性率,过敏原检测可以了解结核患者的过敏体质状况,是否为肝损发生的易感人群,从而对结核患者的临床用药有一定的指导意义。

Objective： To discuss the clinical significance of allergy testing in patients with anti-tuberculosis drug-induced Liver Injury. Methods： 483 cases with anti-tuberculosis DILI were given test serum allergens, and 450 cases without anti-tuberculosis DILI were compared as control. Results： The positive rate of serum allergens in 483 DILI cases was 62. 5%（ 302 /483）, And serum specific allergen positive rate of control group was only 21.3%（96/450）, there was statistically significant difference between the two groups（ P0.01） There was also statistically significant difference between the two groups both in positive rates of inhaled allergens and food allergens（ P0.01）. Conclusion： Patients with anti-tuberculosis DILI had higher allergens tested positive rate, it can help know about allergen situation and risk population for liver injury caused by anti-tuberculosis through serum allergens detection, which have a guiding role in terms of clinical medicine for tuberculosis patients.