益气健脾祛斑汤治疗脾虚血瘀型黄褐斑61例

Yiqi Jianpi Quban Decoction in Treating Melasma of Spleen Deficiency and Blood Stasis for 61 Cases

目的研究益气健脾祛斑汤治疗脾虚血瘀型黄褐斑的疗效及机理。方法将61例黄褐斑患者随机分为治疗组(益气健脾祛斑汤组)和对照组(人参健脾丸组)。治疗2个月后评价治疗效果。结果治疗前后比较,临床疗效显著提高,黄褐斑评分显著降低,有显著差异(XP<0.01),SOD酶有显著升高(※P<0.01),MDA酶明显降低(□P<0.05),治疗组优于对照组。结论益气健脾祛斑汤临床疗效好且无毒副作用,其机理是通过升高SOD酶,降低MDA酶水平达到祛斑作用的。

Objective To research the clinical effect and mechanism of Yiqi Jianpi Quban decoction in treating melasma of spleen deficiency and blood stasis. Methods 61 cases of melasma patients were randomly divided into treatment group（Yiqi Jianpi Quban decoction group） and control group（ Renshen Jianpi pills group）. After 2 months, the clinical effect was evaluated. Results Comparison of pretherapy and post-treatment, the clinical effects and the melasma scores in the two groups were significant different（XP〈0.01）. SOD enzyme was increased significantly（^※P〈0.01）, and MDA enzyme was obviously decreased（ ^XP〈0.05）. The treatment group was better than the control. Conclution Yiqi Jianpi Quban decoction in treating melasma has good clinical effect and no toxic effect. It removed melasma through increasing SOD enzyme and decreasing MDA enzyme.