加减天王补心丹治疗围绝经期妇女失眠症120例临床观察

Clinical Observation of Modifi ed Tianwang Buxin Pill in Treating 120 Cases with Female Insomnia at the Perimenopausal Period

目的:观察加减天王补心丹对于围绝经期妇女失眠的改善作用及停药短期复发情况。方法:将240例围绝经期失眠属阴虚火旺型患者随机分为治疗组与对照组各120例,分别给予加减天王补心丹与替勃龙片联合佐匹克隆口服15天,观察2组疗效与匹兹堡睡眠质量指数(PSQI)积分;停药15天后统计2组PSQI积分并与停药时积分比较计算差值,观察2组差值变化。结果:治疗组和对照组治疗围绝经期失眠的有效率分别为97.5%和98.3%(P<0.05),愈显率则为75.0%和67.8%(P<0.05);2组PSQI积分改善无显著差异(P>0.05);停药15天后2组PSQI积分差值比较具有显著差异(P<0.05)。结论:加减天王补心丹治疗围绝经期妇女失眠效果良好,且作用持久,短期复发率低。

Objective： To observe the therapeutic effect and relapse situation after the treatment of modified Tianwang Buxin pill in treating female insomnia at the perimenopausal period. Methods： 240 cases of perimenopausal patients with insomnia were randomly divided into treatment group and control group, each group of 120 cases. Respectively, modified Tianwang Buxin pills and tibolone tablets combined with zopiclone oral 15 days.The efficacy and Pittsburgh Sleep Quality Index（PSQI） scores were observed. After 15 days of withdrawal, PSQI scores were calculated and compared with the scores at the time of discontinuation. Results： The effective rates of treatment group and control group were 97.5% and 98.3% respectively（P 0.05）. Obvious curative rate was 75.0% and 67.8%, respectively（P 0.05）. There was no significant difference in PSQI score between the two groups（P 0.05）. There were significant differences in PSQI scores between the two groups after 15 days of drug withdrawal（P 0.05）. Conclusion： Modified Tianxin Buxin pill has a good effect on insomnia in perimenopausal women, and its role in lasting, and low recurrence rate.