冠心病合并抑郁症的人群分布特征及临床分析

Epidemiological and clinical characteristics for patients of coronary heart disease associated with depressive symptoms

目的：研究冠心病合并抑郁症患者的年龄、性别和教育特征,分析抗抑郁治疗的作用及临床表现,全面了解我国冠心病合并抑郁症积累相关数据。方法：随机选取广州医科大学附属第二医院门诊及住院的冠心病合并抑郁症志愿者,按患者意愿分为冠心治疗组423例和双心治疗组265例,并以同期进行的2 198例抑郁症调查结果为基线,采用t检验和Mantel-Haenszel分层分析方法研究冠心病合并抑郁症的人群特征和抗抑郁治疗效果。结果：1女性患者发生冠心病合并抑郁症的风险显著高于男性,RR=1.70（P=0.05,CI=1.08-3.47）;2进行抗抑郁治疗的冠心病患者MACE显著低于对比组,差异有统计学意义（P〈0.05）。结论冠心病患者更容易并发抑郁症,而55~64岁中老年女性是冠心病合并抑郁症的高风险人群。

Objective This work studies the epidemiological and clinical characteristics of ages, genders and education level for the patients of coronary heart disease associated with depressive symptoms. Method The volunteered patients coronary heart disease associated with depressive symptoms were categorized into two groups （265 cases for anti - depressive treatments with contrasts of 423 cases） to investigate effects of anti - depressive treatments by t - test and stratified analysis based on the Mantel - Haenszel model, where the results of epidemiological survey of 2 198 samples conducted in the same period were used as the baseline. Results ①the female patients had significantly high risks to occur the depressive symptoms, RR = 1.70 （ P = 0. 05, CI = 1.08 - 3.47） ; ②the anti - depressive treatments can effectively reduce the MACE （ P 〈 0. 05）. Conclusion The patients, especially females at the age range of 55 to 64, with coronary heart disease have extreme high risks to be complicated by the depressive symptoms.