复发缓解型多发性硬化采用干扰素β-1b治疗的疗效解析

Efficacy of Interferon Beta-1b in Relapsing Remitting Multiple Sclerosis

目的探讨复发缓解型多发性硬化采用干扰素β-1b治疗的疗效。方法选取40例复发缓解型多发性硬化患者,给予干扰素β-1b治疗,回顾分析其效果。结果治疗后患者EDSS、HAMD、MSQOL-54评分及T2序列病灶数目及强化病灶数目均优于治疗前(P<0.05);随访2年,共13例复发,占32.5%。结论采用干扰素β-1b对复发缓解型多发性硬化患者进行治疗可有效改善患者装残疾状况及生活质量,临床价值显著。

Objective To investigate the curative effect of relapsing remitting multiple sclerosis using interferon beta 1b therapy. Methods 40 cases of relapsing remitting multiple sclerosis were given interferon beta-1b for treatment,and the effefc was retrospectively analyzed. Results After treatment,patients with EDSS,HAMD,MSQOL-54 score and T2 sequence number of lesions and the number of enhanced lesions were significantly higher than those before treatment（P〈0.05）. Two years of follow-up,a total of 13 cases of recurrence,accounting for 32.5%. Conclusion The use of interferon beta-1b for the treatment of patients with recurrent and multiple sclerosis can effectively improve the condition of disability and quality of life of patients,and with significant clinical value.