卡介菌多糖核酸穴位注射联合阿昔洛韦治疗频繁复发性生殖器疱疹的疗效观察

The Clinical Efficacy of BCG Polyose Nuclear Acid Injection in Acupoint Injection Combined With Acyclovir in the Treatment of Frequently Relapsing Genital Herpes

目的探讨卡介菌多糖核酸注射液穴位注射联合阿昔洛韦治疗频繁复发性生殖器疱疹的临床疗效。方法前瞻性随机对照设计,选取符合病原学诊断标准的120例频繁复发性生殖器疱疹患者,平均分配到实验组和对照组,每组60例。对照组采用阿昔洛韦(400 mg,口服,每日2次)长期抑制疗法,实验组在对照组基础上联合卡介菌多糖核酸注射液穴位注射(0.5 ml,双侧曲池穴,隔日1次),两组疗程均为4个月。对比两组皮损愈合时间、症状消退时间和不良反应,随访1年观察两组复发情况。结果治疗结束后,实验组皮损愈合时间、症状消退时间均少于对照组(P<0.05),随访1年实验组复发率低于对照组(P<0.05)。两组治疗期间不良反应发生率相近(P>0.05)。结论卡介菌多糖核酸注射液穴位注射联合阿昔洛韦治疗频繁复发性生殖器疱疹安全可靠,有助于提高疗效、减少复发。

Objective To investigate the clinical efficacy of acupoint injection BCG polyose nuclear acid injection combined with acyclovir in the treatment of frequently relapsing genital herpes. Methods 120 cases of frequently relapsing genital herpes acquired pathogen diagnosis were randomly divided into experimental group and control group,with 60 cases in each group. The control group were treated with a long-term immunosuppressive therapy of acyclovir（400 mg,oral,2 times daily）,the experimental group was given BCG polyose nuclear acid injection（0.5 ml,bilateral Quchi,1 time every other day） based on the control group,the two groups were treated for 4 months. The healing time,symptom resolution time,adverse reaction and one-year recurrence rate were compared between the two groups. Results After the treatment,the healing time and the time of symptom remission in the experimental group were significantly less（P〈0.05）,and the recurrence rate of the experimental group was significantly lower（P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P〈0.05）. Conclusion The acupoint injection of BCG polyose nuclear acid injection combined with acyclovir in the treatment of frequent recurrent genital herpes is safe and reliable. It is helpful to improve the curative effect and reduce recurrence.