沙利度胺与柳氮磺吡啶治疗强直性脊柱炎的疗效比较

Analysis of Curative Effect by Thalidomide and Sulfasalazine in the Treatment of Ankylosing Spondylitis

目的对比沙利度胺与柳氮磺吡啶治疗强直性脊柱炎的疗效。方法 40例强直性脊柱炎患者随机分为实验组和对照组,每组20例。实验组采用沙利度胺治疗,对照组采用柳氮磺吡啶治疗,观察两组患者的C反应蛋白、红细胞沉降率、D-二聚体、Bath强直性脊柱炎功能指数(BASFI)、外周关节肿胀数、扩胸度及临床症状缓解时间的情况。结果实验组的各项指标在治疗后均优于对照组(P<0.05)。结论沙利度胺治疗强直性脊柱炎能够有效缓解症状,疗效显著。

Objective To analyze the clinical effect by thalidomide and sulfasalazine in the treatment of ankylosing spondylitis（AS）. Methods A total of 40 patients with ankylosing spondylitis were randomly divided into experimental group and control group,with 20 cases in each group. The experimental group given thalidomide for treatment,and the control group given sulfasalazine for treatment for treatment. C-reactive protein,erythrocyte sedimentation rate,D-dimer,Bath Ankylosing Spondylitis Functional Index（BASFI）,peripheral swollen joint count,chest expansion degree,and clinical relief time in both groups were observed. Results The experimental group had all better indexes after treatment than the control group（P〈0.05）.Conclusion Thalidomide can effectively relieve symptoms in treating ankylosing spondylitis,along with precisely curative effect.