摘要
背景右美托咪定（dexmedetomidine，Dex）为高选择性的α2肾上腺素受体激动药，近年来发现其不仅对心、脑、肝、肾等重要器官有保护作用，而且在脓毒症休克复苏、术中控制性降压及酒精戒断治疗等领域中具有重要作用。目的概述Dex实验和临床研究的最新进展，为Dex的临床新应用提供相关依据。内容重点阐述了Dex的器官保护作用、抗脓毒症休克效应、控制性降压作用及抗酒精戒断症状作用。趋向Dex的器官保护作用、抗脓毒症休克效应、控制性降压效应及抗酒精戒断症状效应和其相关机制，将成为Dex临床应用研究的新热点。
Background Dexmedetomidine （Dex） is a highly selective α2 adrenoreceptor agonist. Increasing evidences show that Dex not only has a positive effect on the protection of vital organs, like heart, brain and liver, but also plays critical roles in septic shock resuscitation, controlled hypotension and alcohol withdraw. Objective To review the pharmacological effects of Dex, thus to provide scientific basic for its clinical use. Content The relative published articles were collected from PubMed, Ovid Medline and Springer. Present analysis mainly focused on the effects of Dex on organ protection, septic shock resuscitation, alcohol withdraw and controlled hypotension. Trend The effects of Dex mentioned above and its mechanism will become a new hotpots problem.
出处
《国际麻醉学与复苏杂志》
CAS
2016年第12期1121-1124,1134,共5页
International Journal of Anesthesiology and Resuscitation
基金
江西省卫计委科技计划项目（20131048）
