神经炎症反应在术后认知功能障碍中作用的研究进展

Research progression of the role of neuroinflammation in postoperative cognitive dysfunction

背景在老年患者的心脏手术和非心脏手术中，术后认知功能障（postoperative cognitive dysfunction，POCD）已经成为一种常见的并发症。POCD导致患者并发症增加，医疗消耗增加，患者病死率升高。近年来大量研究发现POCD各种发病机制都通过一个共同通路即神经炎症。目的进一步研究神经炎症反应对POCD发生、发展的作用机制和防治措施。内容以神经炎症反应为中心，围绕神经炎症、炎症因子、抗炎和炎症抑制反应对POCD的影响进行综述。趋向预防性抗炎治疗防止POCD的发生、发展。

Background Postoperative cognitive dysfunction（POCD） often occurs in elderly patients who had cardiac or noncardiac surgeries. POCD results in an increasing of morbidity and mortality and requires more healthcare resources. Recent studies suggest that neuroinflammation plays a major role in POCD. Objective Further investigation of the mechanism of neuroinflammation in POCD and preventive strategies. Content This article reviewed the impact of neuroinflammation, inflammation cytokines, anti-inflammation and inflammation suppression on POCD. Trend Prophylactic administration of antiinflammation drugs as a preventive strategy of POCD.