黏着斑激酶在机械通气相关性肺损伤中的作用

The role of focal adhesion kinase in ventilator-induced lung injury

背景机械通气相关性肺损伤（ventilator_induced lunginjury，VILI）是指应用呼吸机过程中由于机械通气的各种因素与肺部原发病共同作用导致的肺组织损伤。肺损伤过程中肺微血管的完整性破坏及通透性改变是引起VILI的根本原因。紧密连接（tight junction，TJ）及黏附连接（adherent junction，AJ）是细胞连接的主要方式，对维持肺的正常功能起着重要作用。黏着斑激酶（focal adhesion kinase，FAK）主要作用于细胞膜黏附连接的黏着斑部位，能维持黏着斑蛋白在细胞膜的表达，对AJ及血管通透性具有重要作用。目的通过对FAK在VILI中的作用的研究指导临床实践。内容探讨机械通气对FAK的影响及FAK对AJ、TJ的影响和作用。趋向进一步明确FAK在VILI发生过程中的作用，为临床预防及治疗VILI提供新思路及理论依据。

Background Ventilator-induced lung injury（VILI） refers to the pulmonary edema and other pathological changes of lung in the process of applying ventilator.It has been considered that the fundamental reason of VILI is pulmonary microvascular endothelial barrier dysfunction. Adherent junction （A J） and tight junction （TJ） are important components of cell adhesion, which maintain the stability and permeability of endothelial barrier. Focal adhesion kinase（FAK） is a tyrosine kinase which is essential in the maintenance of endothelial barrier properties, and inhibition of FAK activity leads to leaky microvessels. Objective To elaborate the role of FAK in VILI and its clinical application. Content This review will discuss the research progress of how mechanical ventilation affects FAK and how FAK affects AJ and TJ and in VILI. Trend Provide a new theoretical basis for prevention and treatment of ventilator-induced lung injury in clinical.