红细胞分布宽度和hs-CRP与PCI术后对比剂肾病相关性研究

Relationship between red cell distribution width, hs-CRP and contrast-induced nephropathy in patients after PCI

目的 探讨急性冠状动脉综合征患者行冠状动脉介入治疗后出现对比剂肾病与红细胞分布宽度和高敏C反应蛋白之间的相关性.方法 抽取2012年5月至2015年7月本院接诊的300例急性冠状动脉综合征的患者作为研究对象,所有患者均行冠状动脉介入治疗,其中70例出现对比剂肾病,作为观察组;另230例未出现对比剂肾病,作为对照组.对患者进行生化指标的检查,分别观察红细胞分布宽度、高敏C反应蛋白等指标的变化情况.结果 两组患者的血肌酐、尿酸、血红蛋白、红细胞分布宽度及高敏C反应蛋白的指标比较差异有统计学意义（P＜0.05）.经Logistic回归性分析,血肌酐、尿酸、血红蛋白、红细胞分布宽度、高敏C反应蛋白以及慢性完全闭塞病变与对比剂肾病的发生显著相关（P＜0.05）,其中血肌酐、红细胞分布宽度以及高敏C反应蛋白为对比剂肾病的独立危险因素.结论 红细胞分布宽度及高敏C反应蛋白与行冠状动脉介入治疗的急性冠状动脉综合征患者出现对比剂肾病有着密切的关联性,两者均为对比剂肾病的独立危险因素,可作为预测该疾病的主要指标.

Objective To explore the predictive value of red cell distribution width （RDW） and high sensitivity C-reactive protein（hs-CRP） level for contrast-induced nephropathy （CIN） in patients of acute coronary syndrome （ACS） with percutaneous coronary intervention （PC1）. Methods To extract 300 cases of Acute coronary syndrome patients from May 2012-July 2015 as the research objects, all patients underwent coronary intervention, there were 70 patients had Contrast-induced nephropathy, as Observer Group, and the other 230 patients an the control group. Patient examination and biochemical indexes were observed changes in red blood cell distribution width, high-sensitivity C-reactive protein and other indicators. Results The difference of serum creatinine, uric acid, hemoglobin, red blood cell distribution and high-sensitivity C-reactive protein had significant differences, there was statistical significance（P〈0.05 ）. The Logistic regression analysis, creatinine, uric acid, hemoglobin, red blood cell distribution width, high-sensitivity C-reactive protein, and chronic total occlusion lesions with contrast- induced nephropathy was significantly associated （P〈0.05）, and the serum creatinine, red cell distribution width and high-sensitivity C-reactive protein was independent risk factor of contrast-induced nephropathy. Conclusion Red cell distribution width and high-sensitivity C-reactive protein and coronary interventional therapy in patients with acute coronary syndrome contrast nephropathy closely relevance, both of which are independent of contrast nephropathy risk factors as a predictor of the disease the main index.