曲美他嗪对心肌缺血再灌注损伤患者心功能的影响

Effect of Sibutramine Trimetazidine on serum biochemical levels and heart function of patients with myocardial ischemia reperfusion injury

目的 探讨曲美他嗪对心肌缺血再灌注损伤患者心功能的影响.方法 选取广水市第二医院2013年5月至2015年5月期间进行PCI治疗的心绞痛患者110例作为研究对象,按照随机数表法将其随机分为观察组55例和对照组55例.两组患者均进行PCI治疗,并予以常规药物治疗.观察组患者在上述治疗基础上,服用曲美他嗪.观察两组患者血清生化水平及心功能的变化.结果 观察组患者术后6h和术后24 h血清cTnI和CK-MB含量都明显低于相应时间段的对照组患者,差异有统计学意义（P＜0.05）.术后1个月,观察组患者的左室射血分数为（64.3±7.5）％,明显高于对照组的（50.2±7.6）％,差异有统计学意义（t=9.79,P=0.00）.术后3个月,观察组患者的左室射血分数为（65.8±7.8）％,明显高于对照组的（57.1±7.4）％,差异有统计学意义（t=6.00,P=0.00）.观察组患者心血管不良事件发生率为10.91％（6/55）,明显高于对照组的41.82％（23/55）,差异有统计学意义（x2=11.00,P=0.00）.结论 PCI配合曲美他嗪能显著改善手术所致心肌缺血再灌注带来的损伤,进一步改善治疗后患者的心功能.

Objective To investigate effect of Sibutramine Trimetazidine on serum biochemical levels and heart function of patients with myocardial ischemia reperfusion injury. Methods Selected 110 cases with angina pectoris treated with PCI treatment in our hospital from May 2013 to May 2015 as the research object. According to the random number method, they were divided into observation group （55 cases） and control group （55 cases）. Two groups of patients were treated with PCI and conventional drug therapy. The patients in the observation group were treated with Sibutramine Trimetazidine on the basis of above treatment. The changes of serum biochemical level and cardiac function in the two groups were observed. Results The cTnI value and CK-MB value of 24 h in the observation group were significantly lower than those in the control group at the corresponding time period after operation 6 h and after operation 24 h, the difference was significant （P〈0.05）. At 1 months after operation, the left ventricular ejection fraction of the observation group was（64.3±7.5 ）%, which was significantly higher than that of the control group （50.2±7.6）%, the difference was significant （t=9.79, P=0.00）. At 3 months after operation, the left ventricular ejection fraction of the observation group was（65.8±7.8）%, which was significantly higher than that of the control group （57.1±7.4）%, the difference was significant （t=6.00, P=0.00）. Adverse cardiovascular event occurrence rate of the observation group patients was 10.91%（6/55 ）, which was significantly higher than the control group 41.82% （23/55）, the difference was significant （x2=11.00, P=0.00）. Conclusion PCI with Trimetazidine surgery significantly improved injuries caused by the myocardial ischemia reperfusion and further im- proved cardiac function of patients after treatment.