ACEI类药物联合利尿剂对高血压的疗效观察

The curative effect observation of ACEI in combination with diuretics for hypertension

目的 探讨ACEI类药物联合利尿剂对高血压的临床疗效.方法 以本院2013年12月至2016年1月接诊的高血压患者为研究对象,随机选择符合纳入标准的100例纳入此次研究,将数字表法作为研究分组原则,共设定2组.对照组49例,均采取单纯ACEI类药物洛汀新进行治疗.观察组51例,在对照组治疗的基础上联合使用利尿剂呋塞米.比较两组的降压效果.结果 观察组患者的临床治疗总有效率显著高于对照组（98.24％比85.71％,P＜0.05）.治疗后两组患者血压水平较治疗前均有明显降低,观察组治疗后的舒张压和收缩压分别为（91.5±4.8）mm Hg、（132.7±11.2）mm Hg,对照组治疗后的舒张压和收缩压分别为（97.4士5.6）mm Hg、（140.4±11.4）mm Hg,但观察组的改善效果更为显著（P＜0.05）.治疗前两组患者的TNF-α、IL-6、hs-CRP比较,均未见统计学差异（P均＞0.05）;治疗后两组患者的TNF-α、IL-6、hs-CRP与治疗前比较显著降低,差异有统计学意义（P＜0.05）;治疗后观察组的TNF-α、IL-6、hs-CRP[（1.36士0.58）μg/L、（10.24±6.35）μg/L、（5.02±3.25）μg/L]与对照组[（l.67±0.61）μg/L、（14.76±7.91）μg/L、（7.23±3.67）μg/L]比较显著降低,差异有统计学意义（P＜0.05）.治疗期间两组患者均未出现因药物所致的严重不良反应.结论 使用ACEI类药物联合利尿剂治疗高血压,可显著提高临床治疗效果,有效控制患者的血压水平,减少炎性反应,减少炎性因子合成,而且无明显不良反应,安全性较高,值得临床推广.

Objective To investigate the clinical effect of ACEI combined with diuretics on hypertension. Methods 100 hypertensive patients admitted in our hospital from December 2013 to January 2016 were randomly selected to be included in the study. The digital table method was used as the study grouping principle. 49 patients in the control group were treated with ACEI alone. 51 patients in the observation group, in the control group based on the joint use of diuretics furosemide. Comparison of the two groups of antihypertensive effect. Results The total effective rate of clinical treatment in observation group was significantly higher than that in control group（98.24% vs 85.71%, P〈0.05 ）. After treatment, the diastolic blood pressure and systolic blood pressure of the observation group （91.5±4.8）mm Hg and （132.7±11.2）mm Hg, and the diastolic and systolic blood pressure of the control group were （97.4±5.6）mm Hg, （140.4±11.4）mm Hg, but the improvement of the observation group is more sig- nificant （P〈0.05）. After treatment, the levels of TNF-α, IL-6, hs-CRP and TNF-α, IL-6 and hs-CRP in the two groups had no significant difference（P〉0.05） were significantly lower than those before treatment（P〈0.05 ）. Af- ter treatment, TNF-α, IL-6 and hs-CRP [ （ 1.36±0.58）μg/L, （ 10.24±6.35）μg/L, （5.02±3.25）μg/L] in the ob- servation group were significantly lower than those in the control group [ （1.67 ±0.61 ）μg/L, （14.76＋7.91）μg/L, （7.23＋3.67）μg/L] （P〈0.05）. There was no serious adverse drug reaction in both groups. Conclusion ACEI drugs combined with diuretics in the treatment of hypertension, can significantly improve the clinical treatment, ef- fective control of blood pressure levels, reduce inflammatory response, reduce inflammatory factor synthesis, and no significant adverse reactions, high safety, worthy of clinical promotion.