不同海拔地区酒精性肝病现状分析

The current status analysis of alcoholic liver disease in different altitudes

目的：根据相关临床资料统计分析青海果洛达日（4200m）、青海西宁（2261m）、四川郫县（565m）三个海拔地区居民酒精性肝病患病现状。方法：收集不同海拔地区酒精性肝病与正常组样本，每地区选取500例（正常对照组300例、饮酒组200例）。结果：酒精性肝硬化、酒精性脂肪肝、酒精性肝炎、轻症酒精性肝损伤等四种常见酒精性肝病在不同海拔地区的患病率无显著性差异（P〉0．05）；不同海拔地区内酒精性肝病分型之间有显著性差异（P〈0．05），主要以轻症酒精性肝病为主。传统实验室指标与CDT亚型DST比较结果均有显著性差异（P〈0．05）。结论：酒精所致的肝脏损害已经在中国成为一个不可忽视的问题，应加强防治工作。CDT亚型DST对酒精性肝病的诊断率明显高于传统实验室指标，DST可作为目前最好的标志物应用与临床．

Objective： To analyze the current status of alcoholic liver disease in three different altitudes areas,including qinghai go luo da day （4200 m） , qinghai xining （2261 m） , sichuan province PI county residents （565 m） , according to the statistical analysis of clinical data. Methods： 500 cases, including 300 cases of normal control group and alcohol group 200 cases, was collected and analyzed in each region of different altitudes. Results： There was no significant difference about the four common alcoholic liver disease prevalence in different altitudes, including alcoholic cirrhosis, alcoholic fatty liver, alcoholic hepatitis, mild alcoholic liver injury （P〉0.05） . Significant difference was found for alcoholic liver disease classification in different altitudes （P〈0.05） , mainly in mild alcoholic liver disease. Significant difference was also proved about traditional laboratory indexes and the CDT subtype of DST comparison results （P〈0.05） . Conclusion： Liver damage induced by alcohol has become a noticeable problem in China, and the prevention and control work should be strengthened, CDT subtype of DST for the diagnosis of alcoholic liver disease is significantly higher than the traditional laboratory index, and DST could be used as the best marker for clinical application.