不同全身麻醉方法对腹腔镜胆囊切除术后早期认知功能的影响

Influence by different general anesthesia measures on early cognitive function after laparoscopic cholecystectomy

目的研究不同全身麻醉方法对腹腔镜胆囊切除术后早期认知功能的影响。方法 72例腹腔镜胆囊切除术患者,按照随机数字表法分为研究组与对照组,每组36例。对照组患者选择全程吸入麻醉,研究组则选择全凭静脉麻醉,观察两组患者麻醉前后的认知功能评分,并进行对比。结果麻醉前,两组患者认知功能评分比较差异无统计学意义(P>0.05);麻醉后1 d,研究组记忆水平(27.47±1.11)分、语言水平(25.33±1.49)分、计算水平(24.12±2.94)分、注意力水平(26.88±1.86)分,明显高于对照组的(18.16±1.24)分、(17.36±1.91)分、(15.97±2.3)分、(18.88±2.02)分,差异具有统计学意义(P<0.05)。结论相对全程吸入麻醉,以全凭静脉麻醉在腹腔镜胆囊切除术中运用,对患者早期认知功能产生的影响较小,存在临床推广意义。

Objective To research influence by different general anesthesia measures on early cognitive function after laparoscopic cholecystectomy. Methods A total of 72 patients receiving laparoscopic cholecystectomy were divided by random number table into research group and control group, with 36 cases in each group. The control group received whole inhalation anesthesia, and the research group received total intravenous anesthesia. Observation and comparison was made on cognitive function scores before and after anesthesia between the two groups. Results Before anesthesia, there was no statistically significant difference of cognitive function score between the two groups（P〈0.05）. In 1 d after anesthesia, the research group had all higher memory level as（27.47±1.11）points, language level as（25.33±1.49）points, calculation level as（24.12±2.94）points and attention level as（26.88±1.86）points than（18.16±1.24）,（17.36±1.91）,（15.97±2.3）and（18.88±2.02）points in the control group. Their difference had statistical significance（P〈0.05）. Conclusion Comparing with whole inhalation anesthesia, implement of total intravenous anesthesia in laparoscopic cholecystectomy shows less influence on early cognitive function, and this method contains significance for clinical promotion.