原发性皮肤淀粉样变中西医治疗进展

Advances in the Primary Cutaneous Amyloidosis Treated with Integrated Chinese and Western Medicine

原发性皮肤淀粉样变(PCA)的中西医治疗各有所长,中医内治法在辨证论治基础上全面调理,远期治本效果好;中医外治法有熏蒸、贴棉灸、体膜等方法,用药简便,不良反应小,复发率低;西医治疗PCA有糖皮质激素类、维A酸类、环磷酰胺、他克莫司和物理疗法等方法,靶向作用强,短期治标效果好,但毒副作用明显并易反复发作。中西医结合疗法治疗PCA可以弥补彼此缺陷,减低毒副作用,提高临床疗效,中西医结合治疗PCA是切实可行、值得推广的方法。参考文献27篇。

Both Traditional Chinese medicine（TCM） and western medicine have advantages in the treatment of primary cutaneous amyloidosis（PCA）. Based on syndrome differentiation,long-term effect of internal therapies of TCM is good,and external therapies of TCM include fumigating and steaming,cotton moxibustion and body membrane,with the advantage of convenient application,less side effect and low recurrence rate. Western medical therapies usually involve glucocorticoid（GCS）,tretinoin,cyclophosphamide（CTX）,tacrolimus（Tac）and physiotherapy. The target effect is obvious and good short term effect,but the toxic and side effect is obvious with high recurrence rate. Integrated Chinese and western treatment can overcome the disadvantages of each other,reduce toxic and side effect and improve curative effect. Integrated Chinese and western treatment for PCA is practical and feasible and should be promoted.