生长激素在卵巢储备功能低下患者IVF治疗中的应用

An application research of growth hormone on Ovarian reserve dysfunction patients in IVF cycle

目的探讨生长激素在体外受精-胚胎移植中对卵巢储备功能低下患者控制性超排卵的作用。方法将符合卵巢储备功能低下患者的不孕症患者,随机分为生长激素组(50例)和对照组(50例),均采用拮抗剂方案,其中生长激素组从周期第2-3d每天注射4.5IU生长激素直至HCG日,比较两组超排卵的治疗过程及结局。结果两组患者在年龄、基础FSH及E_2水平、窦卵泡数目方面比较均无显著差异。研究组的Gn使用天数以及Gn用量低于对照组,差异有显著性(P<0.05);研究组的获卵数目以及HCG日E_2水平高于对照组,差异有显著性(P<0.05)。研究组的受精率、卵裂率、优胚率略高于对照组,但差异无显著性(P>0.05);研究组的HCG日子宫内膜厚度、P水平略高于对照组,差异无显著性(P>0.05)。结论在卵巢储备功能低下患者,在促排卵过程中加用生长激素可以降低Gn的使用量,增加获卵数及HCG日雌激素的水平。

Objective： To investigale the application of GH to the patients with Ovarian reserve dysfunction. Methods： 100 infertility patients with Ovarian reserve dysfunction were divided into GH group and control group in random. Each cycle was used the antagonist protocol, the patients in GH geoup were administrated GH 4.5IU everyday from menstruation 2-3 days. The processe of controlled ovarian hyperstimulation and outcome were compared. Results： There were no significant differences in age, basal FSH and E2 levels, and the number of antral follicles between the two groups. The doses and duration of gonadotropin in the study group was lower than that in the control group, the difference was significant （P〈0.05） ; the number of oocytes retrieved and the mesh 17 beta-estradiol levels on the day of HCG were higher in the study group than in the control group, the difference was significant （P〈0.05） . Research group in the fertilization rate, cleavage rate, good quality embryo rate slightly higher than that of control group, but the difference was not significant （P〉0.05） ; The uterine endometrial thickness and P levels on the day of HCG in study group wre slightly higher than that in control group, the difference was not significant （P〉0.05） . Conclusion： In patients with low ovarian reserve function, combined with growth hormone during the controlled ovarian hyperstimulation will reduce the doses of gonadotropin, increase the number of oocytes retrieved and the mesn 17 beta-estradiol levels on the day of HCG.