富氢水治疗新生儿缺氧缺血性脑病疗效分析

The efficacy of hydrogen water in the treatment of neonatal hypoxic ischemic encephalopathy

目的探讨富氢水作为辅助方法在新生儿缺氧缺血性脑病（HIE）治疗中的疗效。方法临床选择40例HIE患儿,采用随机方法分为治疗组和对照组,每组20例。治疗组在常规治疗的基础上于生后第2 d加用富氢水治疗,每日5 ml/kg口服,疗程10 d。观察两组患儿平均住院日、临床症状及体征恢复时间,并于生后3 d、7 d、12~14 d进行新生儿行为神经评分（NBNA）。结果治疗组住院时间较对照组减少,差异有统计学意义（P〈0.05）;治疗组前囟张力、意识障碍、肌张力、原始反射恢复时间及惊厥控制时间较对照组明显减少,有显著性差异（P〈0.05）;治疗组3、7、12 d NBNA评分较对照组有统计学意义（P〈0.05）。结论 HIE在常规治疗基础上,加用富氢水能缩短住院时间及临床恢复时间,减少后遗症发生。

Objective： This study the efficacy of hydrogen water in the treatment of neonatal hypoxicischemic encephalopathy（ HIE）. Methods： Forty neonatal with HIE were divided into a conventional care group and a hydrogen water group according to the different treatment methods applied. In the hydrogen water group,5 ml / kg hydrogen water was orally administered two days after birth daily for 10 days in addition to conventional treatment. To observed the average length of stay,the recovery time of clinical symptoms and signs in the two groups. NBNA was performed after the birth of 3 days,7days,12 ~ 14 days. Results After treatment,the average length of stay in the hydrogen water group were lower than those in the conventional group（ P〈0. 05）. The anterior fontanelle tension,disturbance of consciousness,muscle tension,primitive reflex recovery time and convulsions control time in the hydrogen water group were lower than those in the conventional group（ P〈0. 05）. The treatment group NBNA score higher than the control group was statistically significant（ P〈0. 05）.Conclusion Hydrogen water lowers the length of stay and clinical recovery time in HIE newborns,thereby exerting a protective effect.