摘要
板蓝根为十字花科(Cruciferae)植物菘蓝Isatis indigotica Fort.的干燥根,是清热解毒类的代表性中药。以落叶松脂素为代表的木脂素类成分是板蓝根发挥抗病毒活性的重要物质基础。本文综述板蓝根木脂素类成分生源途径解析、关键调控基因筛选和次生代谢工程调控方面的研究进展,为全面认识板蓝根抗病毒活性成分生物合成、提升板蓝根药材品质及促进板蓝根药用资源的可持续利用等奠定基础。
Isatidis Radix, the root of Isatis indigotica Fort.（Cruciferae）, is a representitive herb widely used for clearing away heat-toxin in traditional Chinese medicine（TCM）. Lariciresinol is a representitive component of lignans and an important efficacious substance with the antiviral effect. This review elucidated the progress on its biosynthetic pathways, the screening of key regulatory genes and metabolic engineering of lignans components in Isatidis Radix, providing a favorable reference for the full understanding of biosynthesis of antiviral active components, the quality improvement of Isatidis Radix and the sustainable utilization of TCM resources.
作者
肖莹
马瑞芳
陈军峰
杨颖博
张磊
陈万生
Xiao Ying Ma Ruifang Chen Junfeng Yang Yingbo Zhang Lei Chen Wansheng(Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China School of Pharmacy, Second Military Medical University, Shanghai 200433, China Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)
出处
《世界科学技术-中医药现代化》
2016年第11期1908-1913,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委国家杰出青年科学基金项目(81325024):中药药效物质,负责人:陈万生
国家自然科学基金面上项目(31670292):茉莉酸响应的AP2/ERF转录因子对菘蓝木脂素生物合成的调控作用及其分子机制研究,负责人:张磊
国家自然科学基金青年基金项目(31100221):四倍体菘蓝聚合蛋白酶与松脂醇还原酶的功能及特征研究,负责人:肖莹
国家自然科学基金面上项目(81673550):丹参根系形态、结构特征与有效成分积累的关联性及形成机制研究,负责人:陈军峰
关键词
板蓝根
菘蓝
抗病毒
木脂素
生物合成
Isatidis Radix
Isatis indigotica Fort.（Cruciferae）
antiviral activity
lignan
biosynthesis
