376例药品不良反应分析

Analysis of 376 adverse drug reactions cases

目的为了解医院药品不良反应(ADR)发生的特点及规律,降低不良反应发生率。方法收集陕西省肿瘤医院医院2015年上报的376例ADR报告,按患者性别、年龄、涉及药物、给药途径、ADR涉及的器官或系统及转归等进行统计分析。结果抗肿瘤药物所致ADR居首位(55.59%);以静脉给药(92.81%)引起的ADR最常见;ADR涉及的器官或系统主要为消化系统、皮肤/附件、全身系统,绝大多数ADR转归良好。结论应进一步加强药品不良反应的培训和监测工作,发挥好临床药师的作用,提高医院不良反应上报质量。

Objective To find out the feature of the adverse drug reactions（ ADRS） reported in our hospital,and to decrease the incidence rate of ADR. Methods A total of 376 ADR cases submitted by our hospital from 2015 were analyzed statistically in respect of patients＇ age and sex,the drugs involved,routes of administration,ADR- involved organs or systems,and turnover,etc. Results Of the total 376 cases,55. 59% were induced by antitumor drugs and 92. 81% were induced by intravenous route. The digestive system,lesions of skin and its accessories,and systematic system were the predominant system happening ADR,and the majority ADR cases had a good turnover. Conclusion The training and monitoring of ADR should be further strengthened as well as the clinical pharmacists should play more role on ADR,consequently prompt the quality of ADR reports.