巨噬细胞抑制因子-1及胃泌素释放肽前体水平对肺癌患者的诊断和预后评估价值

Diagnostic and Prognosctic Prediction Value of Macrophage Inhibitory Factor-1 and Pro-gastrin Releasing Peptide Level in Patients with Lung Cancer

目的:研究巨噬细胞抑制因子-1(MIC-1)及胃泌素释放肽前体(pro-GRP)水平对肺癌患者的诊断和预后评估价值。方法:选择2012年5月-2015年6月在我院确诊的50例肺癌患者和35例肺良性占位性病变患者分别作为肺癌组和良性对照组,同一时间段内在我院体检的50例健康者作为健康对照组,采集血清并测定MIC-1、pro-GRP、CEA、CA125、CYFRA21-1、SCC-Ag的含量。结果:肺癌组患者血清中MIC-1、pro-GRP的含量(1.19±0.18 vs 0.42±0.07,0.37±0.05 ng/m L)、(363.62±65.61 vs 62.42±9.61,57.24±8.94 pg/m L)显著高于良性对照组和健康对照组;肺癌患者的TNM分期越高、分化程度越低,血清中MIC-1、pro-GRP的含量越高且远处转移患者的血清MIC-1、pro-GRP含量显著高于未发生远处转移的患者;肺癌组患者血清中CEA、CA125、CYFRA21-1、SCC-Ag的含量显著高于良性对照组和健康对照组并且与血清MIC-1、pro-GRP含量呈正相关。结论:肺癌患者的血清MIC-1和pro-GRP含量显著升高,与肺癌的临床病理特征以及恶性程度均具有相关性。

Objective： To study the predictive value of macrophage inhibitory factor -1 and pro-gastrin releasing peptide level in patients with lung cancer. Methods： 50 cases of patients with lung cancer and 35 cases patients with lung benign lesions diagnosed in our hospital from May 2012 to 2015 June were respectively enrolled in lung cancer group and benign control group, 50 cases of healthy people received physical examination during the same time section in our hospital were enrolled as healthy control group. Serum was collected and MIC-1, pro GRP, CEA, CA125, CYFRA21-1, SCC Ag contents weredetermined. Results： Serum MIC-1 （1.19±0.18 vs 0.42± 0.07, 0.37±0.05 ng/mL）, pro-GRP（363.62± being 65.61 vs 62.42±9.61, 57.24± 8.94 pg/mL） content of lung cancer group were significantly higher than those in benign control group and healthy control group; in patients with lung cancer, the higher the TNM stage and the lower the differentiation degree, the higher the serum MIC-1, pro GRP contents and serum MIC-1, pro-GRP contents of patients with distant metastasis were significantly higher than those without distant metastases; serum CEA, CA125, CYFRA21-1, SCC Ag contents of lung cancer group were significantly higher than those of benign control group and healthy control group and positively correlated with serum MIC-1, pro-GRP contents. Conclusion： The serum MIC-1 and pro-GRP levels of lung cancer patients significantly increase, serum MIC-1 and pro-GRP levels correlate with the clinicopathological characteristics and the degree of malignancy.