Comparison of the effect of low-frequency electroacupuncture on serum leptin and NPY contents of male and female patients with simple obesity

低频电针对男、女单纯性肥胖症患者血清Leptin和NPY含量影响的比较分析（英文）

Objective To explore the difference of low-frequency electroacupuncture in regulating serum leptin and neuropeptide Y（NPY） of male and female patients with simple obesity due to spleen deficiency and damp exuberance. Methods Eighty patients with simple obesity, including 37 males and 43 females, were included in this study. In both groups（male group and female group）, Yīnlíngquán（阴陵泉 SP 9）, Sānyīnjiāo（三阴交 SP 6）, Zúsānlǐ（足三里 ST 36）, Fēnglóng（丰隆 ST 40）, Qūchí（曲池 LI 11）, Tiānshū（天枢 ST 25）, Zhōngwǎn（中脘 CV 12）, Shuǐfēn（水分 CV 9）, Qìhǎi（气海 CV 6）, and Guānyuán（关元 CV 4）. were selected, and low-frequency electroacupuncture treatment was applied. Needles were retained for 30 min. The treatment was conducted once a day, and 10 times were considered as one course of treatment. Two courses were needed. The changes of weight, BMI（body mass index）, F%（fat percentage） and serum leptin and NPY contents of patients in the two groups before and after treatment were observed and analyzed comparatively. Results After treatment, in male group, the weight lost（9.24±2.55） kg, BMI reduced by 4.19±2.30, F% reduced by 3.98±2.13, serum leptin level reduced by（0.66±0.23） ng/m L, and serum NPY level reduced by（18.56±2.89） pg/m L; in female group, the weight lost（6.77±2.31） kg, BMI reduced by 2.65±0.93, F% reduced by 4.98±2.30, serum leptin level reduced by（3.49±1.09） ng/m L, and serum NPY level reduced by（11.21±1.97） pg/m L. The results reduced significantly when compared with the level before treatment（P〈0.05, P〈0.01）. The loss of weight, BMI and serum NPY content in male group was more obvious than that in female group（all P〈0.01）, and the loss of F% and serum leptin content in female group was more obvious than that in male group（both P〈0.01）. Conclusion Low-frequency electroacupuncture can significantly regulate the weight, BMI, F% and serum leptin and NPY contents of male and female patients with simple obesity, and there are gender differences. In terms of reducing weight, BMI and serum NPY content, the efficacy of low-frequency electroacupuncture in males is superior to that in females, while in terms of reducing F% and serum leptin content, the efficacy in females is superior to that in males.

目的:探讨低频电针对男、女脾虚湿盛型单纯性肥胖症患者血清leptin(瘦素)和NPY(神经肽Y)调节作用的差异。方法:纳入单纯性肥胖症患者共80例,男性37例,女性43例。两组均选取阴陵泉、三阴交、足三里、丰隆、曲池、天枢、中脘、水分、气海、关元穴,采用低频电针治疗,留针30min,每天1次,10次为一疗程,治疗2个疗程。观察两组患者治疗前后体质量、BMI(体质量指数)、F%(体脂百分率)及血清leptin和NPY含量变化,并进行比较分析。结果:治疗后男性组患者体重下降(9.24±2.55)kg,BMI下降4.19±2.30,F%下降3.98±2.13,血清leptin下降(0.66±0.23)ng/m L,血清NPY下降(18.56±2.89)pg/m L,女性组分别下降(6.77±2.31,2.65±0.93,4.98±2.30,3.49±1.09,11.21±1.97),与治疗前比较均明显降低(P<0.05,P<0.01),男性组患者体质量、BMI、血清NPY含量较女性组均降低明显(均P<0.01),女性组患者F%、血清leptin含量较男性组均降低明显(均P<0.01)。结论:低频电针对男、女单纯性肥胖症患者体质量、BMI、F%及血清leptin、NPY含量均有明显的调节作用,且存在一定的性别差异,在降低体质量、BMI和血清NPY方面,男性优于女性,而在降低F%、血清leptin方面,女性优于男性。