长链非编码RNA与肺癌

Long Non-coding RNAs and Lung Cancer

肺癌发病率高、预后差,是患者癌症死亡的首要病因;但是肺癌的发病机制尚不完全明确、现有的诊断方法和治疗手段有待进一步提高。长链非编码RNA(long non-coding RNA,lncRNA)是一种长度大于200个碱基、没有或者少有蛋白编码功能的RNA分子,其功能研究是当前研究热点。已有文献显示,lncRNA与肺癌的发生、发展和预后等密切相关,本文就此进行综述。

Lung cancer is the leading cause of cancer-related deaths for males in the world and even females in most of the developed countries with increasing incidence and mortality. Its pathogenesis, therapy, and prognosis are focal points of this area. Long non-coding RNAs（lncRNAs）, a novel class of non-coding RNAs with a length longer than 200 nt and little proteincoding ability, attract more and more attentions. Herein, we discuss the relevance of lncRNAs and lung cancer in order to deepen our understanding on mechanisms underlying the initiation and progression, the identification of novel biomarkers for diagnosis and prognosis, and the development of effective therapeutic targets for lung cancer.