贞芪扶正胶囊联合化疗对中晚期宫颈癌患者的疗效及免疫功能影响

Efficacy of Zhenqi Fuzheng Capsule Combined with Chemotherapy in the Treatment of Middle and Advanced Cervical Cancer and Its Effect on Immune Function

目的:探讨贞芪扶正胶囊联合化疗对中晚期宫颈癌患者的疗效及免疫功能影响。方法:选取60例中晚期宫颈癌患者,按住院单双号分为两组,对照组(29例)采用TP方案化疗,共计2个疗程;观察组(31例)给予贞芪扶正胶囊联合TP方案化疗,共计2个疗程。通过观察并记录患者治疗后疗效,1年内局部复发率,远处转移率,治疗前后免疫功能变化及化疗期间不良反应情况。结果:2个疗程结束后观察组患者有效率明显高于对照组(P<0.05);治疗后1年内,观察组与对照组患者在肿瘤局部复发率和远处转移率上相比没有明显差异(P>0.05);治疗后观察组患者CD4^+T细胞、CD4^+/CD8^+、NK细胞水平明显升高且高于同期对照组患者(P<0.05),CD8^+T细胞水平治疗前后无明显变化;治疗后对照组患者CD4^+T细胞、CD4^+/CD8^+水平明显下降(P<0.05),CD8^+T细胞、NK细胞水平治疗前后无明显变化;化疗期间两组患者在恶心呕吐、肝功能损伤发生率上相比,差异没有统计学意义(P>0.05),白细胞减少、血细胞下降在观察组的发生率明显低于对照组(P<0.05)。结论:贞芪扶正胶囊联合化疗对中晚期宫颈癌患者具有较好的治疗效果,能提高患者免疫功能,减小不良反应,具有一定的临床应用价值。

Objective： To discuss the efficacy of Zhenqi Fuzheng Capsule combined with chemotherapy in the treatment of middle and advanced cervical cancer and its effect on immune function. Methods： 60 patients with middle and advanced cervical cancer were selected and divided into two groups according to odd and even number of hospitalization. The control group （29 cases） was treated with TP chemotherapy for 2 courses treatment, and the observation group （31 cases） was treated with Zhenqi Fuzheng Capsule combined with TP chemotherapy for 2 courses treatment. The efficacy, local recurrence rate, distant metastasis rate, immune fimction change and adverse reactions during treatment were detected and compared between two groups. Results： After 2 courses of treatment, the effective rate of observation group was higher than that of the control group （P〈0.05）. 1 years after treatment, there were no statistical significance on local recurrence and distant metastasis rate between two groups （P〉0.05）. After treatment, the CD4^＋T cell, CD4^＋/CD8^＋, NK cells of observation group was increased significantly and higher than that of the control group （P〈0.05）. There was no statistical significance on CD8^＋ level before and after treatment. After treatment, the CD4^＋T cell, CD4^＋/CD8^＋ of control group was decreased. There were no statistical significance on CD8^＋ and NK cells before and after treatment in the control group. During chemotherapy, there were no statistical significance in nausea, vomiting, liver dysfunction between two groups （P〉0.05）. The incidence that the white blood cells and blood cells were decreased was lower in observation group than that of the control group （P〈0.05）. Conclusion： Zhenqi Fuzheng Capsule combined with chemotherapy has a good therapeutic effect on middle and advanced cervical cancer, which can improve the immune function of patients and reduce the adverse reactions, worthy of clinical value.