元胡止痛胃漂浮型控释片初步研究

Preliminary study on preparation of Yuanhuzhitong HBS Tablet

目的 :探讨元胡止痛片剂型改进为胃漂浮型控释片的制备工艺及质量控制方法。方法 :筛选漂浮型成型辅料 ,并选用延胡索乙素作为对照品 ,采用薄层层析—紫外分光光度法进行含量测定。结果 :供试品起漂时间为 1～ 3min ;主要有效成分延胡索乙素 3h相对溶出度为 32 % ,9h相对溶出度为 86 % ;初步制订质量控制方法。结论 :为制备元胡止痛胃漂浮片提供依据。

Objective: To study the preparation and quality control methods of Yuanhu Zhitong HBS Tablet. Methods: the suitable excipients and formulation process of Yuanhu Zhitong HBS Tablet is sieved by means of testing quantity of tetrahydropalmatine through TLC UV. Results: the beginning floating time of HBS Tablet is 3min; relative dissolution of main component tetrahydropalmatine is 32% within 3hr, 86% within 9 hr. Conclusions: the study is found to be effective in the process of Yuanhu Zhitong HBS Tablet.