3D打印的个性化药物研究进展

Progress in Personalized Drugs Manufactured by 3D Printing

3D打印被誉为"第三次工业革命",它以"逐层打印,层层叠加"的制造概念和独特的优势,被广泛应用于航天、建筑、医药、制造业等众多领域。由于3D打印技术突破了传统药物加工技术的局限,保证其打印的药物结构可控,载药量精确,为打印新型药物剂型和定制个性化药物的发展提供了重要的手段。笔者综述了基于喷墨成型、挤出成型、立体光固化快速成型技术打印的多种剂型的药物,包括个性化片剂、植入剂、载药微针、膜剂等。3D打印将变革药物的加工方式,加速个性化给药时代的来临。

Three-dimensional （3D） printing is regarded as the third industrial revolution. It includes a wide variety of manufactur- ing techniques, which are all based on digitally-controlled depositing of materials （layer-by-layer） to create freeform geometries. It is rapidly developed in various areas including space field, architecture, manufacturing, and pharmaceutical industry. From a medical and therapeutic perspective, 3D printing is of great potential advantage for producing personalized medicines owing to its accurate con- trol of drug structure, precise drug loading. This paper aims to review three different 3 D priming technologies that can be used in phar- maceutics,including inkjet printing, fused-deposition modeling, and stereolithography apparatus to manufacture personalized tablets, implants, drug-containing microneedles, and films. Pharmaceutics is seeing a turning point and that 3D printing ofpersonalized medi- cines and customized dosage forms is set to revolutionize the drug delivery.