宫清颗粒活血祛瘀药效学研究

Pharmacodynamic studies on blood-quickening and stasis-transforming actions of Gongqing Granules

目的 :观察宫清颗粒 (益母草 ,马齿苋 ,蒲黄等 )的活血祛瘀药理作用。方法 :采用优球蛋白溶解试验观察宫清颗粒对大鼠血浆纤溶性的影响 ,采用盐酸肾上腺素造模法观察宫清颗粒对大鼠全血粘度、血浆比粘度、血沉、红细胞压积的影响 ,采用自然出血法、毛细玻管法观察其对小鼠出血时间及对大鼠凝血时间的影响。结果 :该制剂口服具有明显降低肾上腺素造模大鼠全血粘度、血浆比粘度、红细胞压积作用 ;缩短大鼠血浆优球蛋白溶解时间及提高其纤溶活性的作用 ;对小鼠出血时间没有明显影响 ;能缩短大鼠凝血时间。结论 :宫清颗粒具有较强的活血祛瘀作用。

Objective: To evaluate the pharmacological actions on blood quickening and stasistransforming of Gongqing Granules (Herba Leonuri, Herba Portulacae, Pollen Typhae, etc).Methods:Fibrinolysin dissolving, blood stagnation model induced by adrenaline hydrochloride, natural bleeding, capillary coagulation.Results: Gongqing Granules could obviously increase whole blood and plasma viscosities and packed cell volume, and obviously shorten the time of fibrionolysin dissolving. It showed no evident effect on the time of bleeding in mice and could shorten the time of capllary blood coagulation in rats.Conclusion: Gongqing Granules has strong actions of blood quickening and stasis transforming.