摘要
肝脏疾病严重威胁着人类的健康,肝脏实质细胞、肝脏枯否细胞及肝窦内皮细胞、肝脏星形细胞及胆管上皮细胞是组成肝脏的主要细胞,它们所具有的受体与生理学特性为肝脏疾病靶向制剂的设计与应用提供了依据。脂质体制剂具有被动与主动靶向性,依据肝脏疾病的特点,本文综述了靶向于不同肝脏细胞、作用于不同受体的肝脏疾病靶向脂质体。
Liver diseases affect human health seriously. The liver cells include hepatocytes,Kupffer cells,sinusoidal endothelial cells,hepatic stellate cells,and bile duct epithelial cells. Their receptors and physiology functions provide the evidences for design of targeting drug systems for liver diseases treatment. The liposomes with passive and active targeting abilities offer a therapeutic measure to liver diseases. According to the diseases characteristics,we summarized the liposomes which target different liver cells and act on different cells receptors in this paper.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2017年第2期193-196,共4页
Chinese Journal of New Drugs
基金
辽宁省自然科学基金项目(201602312)
关键词
肝脏疾病
受体
靶向
脂质体
liver diseases
receptors
target
liposomes
