全血黏度与脑小血管病的相关性研究

The association study between whole blood viscosity and cerebral small vessel disease

目的探讨全血黏度与脑小血管病(SVD)相关性。方法选取正常对照组35例和脑小血管病组35例,根据头颅MRI表现将SVD组分为脑白质病变(WML)组和腔隙性脑梗死(LI)组,比较SVD组、WML组、LI组与正常对照组的全血黏度及其他脑血管危险因素,并对全血黏度进行多因素Logistic回归分析。结果全血黏度的增高与SVD及WML的发生相关(OR=1.518;1.503),当调整其他危险因素后,P<0.05;全血黏度的增高与LI的发生相关(OR=1.272),然而调整其他脑血管危险因素后,P>0.05。结论全血黏度的增高可能是脑小血管病特别是WML的独立危险因素,其与脑小血管病特别是脑白质病变密切相关。

Objective To investigate the association between whole blood viscosity and cerebral small vessel disease. Method 35 people were chosen for control group, 35 people were chosen as cerebral small vessel disease （ SVD ） group, SVD group was divided into white matter lesions （ WML ） group and lacunar infarction （ LI ） group according to the MRI. We compared the whole blood viscosity and other cerebral-vascular risk factors between SVD group and control group, and used Logistic regression models to assess the association between whole blood viscosity and SVD. Results Higher level of whole blood viscosity was associated with SVD （ OR=1.518 ） and WML （ 0R=1.503 ）, these associations persisted after adjustment for cerebral-vascular risk factors （ P〈0.05 ） . Higher level of whole blood viscosity was also associated with the incident of LI （ 0R=1.272 ）, but the association did not persist after the adjustment for cerebral-vascular risk factors （ P〉0.05 ） . Conclusion Higher level of whole blood viscosity may be an independent risk factor for the incidence of cerebral small vessel disease, in particular, the presence of white matter lesions. Whole blood viscosity is closely associated with cerebral small vessel disease and white matter lesions.