成纤维细胞生长因子2基因多态性与胃癌的关联性研究

Study on association between FGF2 gene polymorphism and stomach cancer

目的研究重庆地区胃癌患者成纤维细胞生长因子2(FGF2)-553 T/A基因多态性与胃癌发病的相关性。方法选取该院2013年10月至2014年10月48例经胃镜或手术病理检查证实的胃癌患者作为胃癌组,并选取该院健康体检中心48例健康个体作为对照组,采用聚合酶链反应-限制性片段长度多态性分析技术检测两组研究对象FGF2-553 T/A基因多态性分布,比较胃癌患者与对照组基因频率的差异。结果胃癌组患者FGF2-553 T/A基因型频率与对照组比较,差异无统计学意义(P>0.05)。结论胃癌患者FGF2-553 T/A基因型与胃癌患病易感性可能没有关联性。

Objective To investigate the association between the fibroblast growth factor 2（FGF2） gene polymorphism and stomach cancer onset among the patients with stomach cancer in Chongqing area. Methods Forty-eight patients with stomach cancer confirmed by gastroscope or operative pathological examination in our hospital from October 2013 to October 2014 were taken as the stomach cancer group. Forty-eight healthy adults undergoing health physical examination were selected as the control group. PCR-RELP was used to detect the gene polymorphism distribution of FGF2-553T/A for comparing the difference of gene frequency between the patients with stomach cancer and control group. Results The gene frequency of FGF2-553T/A had no statistical difference between the patients with stomach cancer and the control group（P〉0.05）. Conclusion The genotype of FGF2-553T/Ain the patients with stomach cancer may have no association with the susceptibility to stomach cancer.