Sirt1与糖稳态

Sirt1 and glucose homeostasis

持续高血糖是胰岛素抵抗和糖尿病的主要特征,糖稳态失衡引起代谢失调,导致糖尿病及其并发症。Sirt1是哺乳动物中一种NAD依赖性的Ⅲ类组蛋白去乙酰化酶,在能量代谢和胰岛素抵抗中发挥重要作用。Sirt1通过降低PGC-1α、NF-κB、Foxo1、Akt等蛋白分子的乙酰化水平来保护胰岛β细胞功能,提高胰岛素敏感性,改善炎症反应,使机体血糖维持在稳定水平。本文就Sirt1调节糖稳态的最新研究进展进行综述。

Sustained hyperglycemia is the basic feature of insulin resistance and type 2 diabetes. Disorders of glucose homeostasis lead to metabolic dysfunction, thus provoking diabetes and diabetic complications. Sirtuin 1 （Sirt1）, a mammalian NAD-dependent protein deacetytase, plays a critical role in energy metabolism and insulin resistance. Recent studies suggest that activation of Sirtl deacetylates various proteins such as PGC-1α, NF-κB, Foxol and Akt, which in turn protects pancreatic β cell functions, improves insulin sensitivity, attenuates inflammation and subsequently maintains glucose homeostasis. This review summarizes recent advances in the role of Sirtl in regulating glucose homeostasis.