乙型肝炎相关肝癌合并门静脉左支与右支癌栓患者根治术后预后研究

A comparison of prognosis of radical resection of hepatitis B-related hepatocellular carcinoma with left portal vein and right portal vein tumor thrombi

目的分析乙型肝炎相关肝癌合并门静脉左支与右支癌栓患者行根治术后预后的差异。方法回顾性分析2008~2012年收治的乙型肝炎相关肝癌合并门静脉左右支癌栓患者26例的随访,所有患者均已行肝切除术。男性12例,女性14例;年龄29~67岁;其中门静脉左支癌栓患者11例;门静脉右支癌栓患者15例。比较两组组患者肝切除术后至复发时间(TTR)及总生存期(OS)。结果门静脉左支癌栓患者无瘤生存期最短为3.6个月,最长为18.5个月;门静脉右支癌栓患者无瘤生存期最短为4个月,最长为15个月。门静脉左支癌栓患者总生存期最短为3.6个月,最长为18.5个月;门静脉右支癌栓患者总生存期最短为4.6个月,最长为20个月。门静脉左支癌栓与右支癌栓的乙型肝炎相关肝癌患者根治术后至复发时间及总生存期均差异无统计学意义。结论门静脉左支癌栓与右支癌栓的乙型肝炎相关肝癌患者根治术后至复发时间及总生存期均差异无统计学意义。

Objective To investigate the prognosis of patients with hepatitis B-related hepatocellular carcinoma （HCC） with left portal vein and right portal vein tumor thrombi undergoing radical resection. Methods Follow-up data of 26 HBV-related HCC patients with left or right portal vein tumor thrombi undergoing radical resection from 2008 to 2012 were retrospectively reviewed. All patients received liver resection for HCC. Among them, 12 were male and 14 were female. Their age was within a range of （29-67） years at diagnosis. Among all patients, 11 had left portal vein tumor thrombi, 15 had right portal vein tumor thrombi. Time to recurrence （TFR） and overall survival time （OS） were analyzed in both groups. Results The TTR and the OS for the patients with left portal vein tumor thrombi ranged from 3.6 to 18.5 months. While the TTR for the patients with right portal vein tumor thrombi ranged from 4 to 15 months, and the OS for those patients ranged from 4.6 to 20 months. There was no significant difference in the TrR or the OS between both groups. Conclusions There is no significant difference in the TrR or the OS between the patients with hepatitis B-related HCC with left portal vein thrombi and those with right portal vein tumor thrombi.