临床药师干预对食管癌化疗患者辅助治疗的影响观察

Effect of Clinical Pharmacist Intervention on Adjuvant Treatment of Esophageal Cancer Patients Undergoing Chemotherapy

目的:探讨临床药师在食管癌化疗患者辅助治疗中的作用。方法:222例食管癌患者按入院先后顺序分为对照组和干预组,临床药师参与医疗团队临床查房和药学查房,对干预组不合理辅助治疗进行干预,观察患者住院期间的住院时间、住院费用、不良事件等信息;对照组通过医院信息系统回顾性调查收集相关资料。结果:临床药师对药物使用的干预占全部不合理辅助治疗干预内容的90.6%,主要包括干预不合理联合用药、用法用量、药物选择、用药疗程等。干预组化疗前、后住院天数,单次住院总天数,一年中住院频次,以及单次住院费用,单次住院辅助药物费用等指标均显著低于对照组(P<0.05或P<0.01)。干预组药品不良反应发生率、意外事件发生率均显著低于对照组(P<0.05)。结论:临床药师通过对不合理治疗问题进行及时干预和提供用药咨询及指导,有效地缩短住院时间,降低住院费用,减少药品不良反应和意外事件的发生,在食管癌化疗患者的辅助治疗中起到积极的作用。

Objective： To explore the role of clinical pharmacists in the adjuvant therapy of esophageal cancer patients undergoing chemotherapy. Methods： 222 esophageal cancer patients were randomly divided into the intervention group and the control group according to the order of admission. Through participating in medical team clinical rounds and pharmaceutical ward rounds,clinical pharmacist timely corrected the unreasonable adjuvant treatment in the intervention group. Observed and recorded the hospitalization time,hospitalization expenses,adverse events and some other informations during the period of hospitalization. The related datas of the control group was collected through the hospital information system retrospectively. Results： Clinical pharmacists corrected the unreasonable auxiliary drug treatment accounted for 90. 6% of total unreasonable adjuvant treatment,especially in unreasonable combination,usage and dosage,drug selection,and drug treatment course. In all cases,whatever the length of stay before chemotherapy or after chemotherapy,the single hospitalization days,the hospitalization frequency,single average total costs of hospitalization,costs of adjuvant drugs,the intervention group were significantly lower than that of control group（ P〈0. 05 or P〈0. 01）. The incidences of adverse drug reaction,accidents,and the interrupted or failure or delay of chemotherapy were significantly lower in intervention group than that in control group（ P〈0. 05）. Conclusion： Clinical pharmacist timely intervented the unreasonable auxiliary drug treatment,and provided recommendations and guidance for drug use,could reduce the occurrence of adverse drug reactions and accidents,shorten the hospitalization time,reduce the hospitalization expenses. They played a very positive role in adjuvant therapy of esophageal cancer patients undergoing chemotherapy.