子宫内膜与卵巢原发性双癌的临床预后分析

Analysis of clinicopathologic and prognosis of patients with synchronous primary carcinomas of the endometrium and ovary

目的探讨子宫内膜和卵巢原发性双癌的临床病理特征、诊治及预后。方法回顾性分析2006年1月至2014年10月在广西壮族自治区人民医院诊断为子宫内膜和卵巢原发性双癌患者临床病理资料。结果 9例患者中位诊断年龄为45岁,临床表现以盆腔包块和异常阴道流血为主。所有患者均接受手术治疗,术后病理检查提示子宫内膜和卵巢原发性双癌病理类型,两种癌分期均为Ⅰ期者8例。8例予术后辅助化疗,1例联合放疗,其中行腹腔化疗4例。术后随访1~68个月,中位数随访时间24个月,现7例均存活,无复发,1例失访,1例死亡。结论子宫内膜和卵巢原发性双癌患者发病年龄轻,多为早期,分化较好,预后好。

Objective To explore the clinicopathologic characteristics, diagnosis, treatment and prognosis in the patients with synchronous primary cancer of the endometrium and ovary. Methods This was a retrospective study. Data of patients with synchronous primary endometrial and ovarian cancers who were treated in gynecologic oncology department of People＇s Hospital of Guangxi Zhuang Autonomous Region Between January 2006 and October 2014 was reviewed. Results The median age of the 9 patients at the time of diagnosis was 45years old. The most common symptoms were abnormal vaginal bleeding and pelvic mass. All patients underwent surgical treatment in our unit. Most common pathologic diagnosis was endometrioid tumors. Among the 9 patients, eight of them had stage I of both endometrial cancer and ovarian cancer. Eight patients received postoperative chemotherapy, 1 patient underwent radical-chemotherapy and 4 patients received intmperitoneal chemotherapy. The median follow-up time was 24 months （range, 1-68 months）. One patient was lost to follow-up, one died and the other seven patients were alived without relapsed. Conclusion Patients with synchronous primary cancer of endometrium and ovary has distinct clinical characteristics including younger age, but they usually presented in early stage with low grade histology which may contribute to the good prognosis.