治疗需氧菌阴道炎的随机对照研究

The study on the therapeutic effects fo r patients with aerobian vaginitis

目的比较氯喹那多-普罗雌烯阴道片(Chlorquinaldol-Promestriene Vaginal Tablets)与克林霉素对需氧菌阴道炎的疗效及复发率的影响。方法对2009年11月至2010年4月北京大学第一医院妇产科门诊诊断的15~60岁确诊为需氧菌阴道炎(aerobic vaginosis,AV)患者共98例,随机分组治疗(A组:氯喹那多-普罗雌烯阴道片1片/日,睡前置入阴道,连续12 d;B组:克林霉素,300 mg/d,阴道上药,连续12 d),随访1个月,并对所得数据统计分析。结果 (1)治疗后7~10 d显效与治愈者30例,总有效率30.6%,其中A组临床有效率为35.4%(17/48),B组26.0(13/50),两组比较(χ~2=1.022,P=0.312,P>0.05),差异无统计学意义;(2)随访1个月后两组的各症状体征P值均大于0.05,差异无统计学意义,疗效判定复发率A组(2/35)5.7%、B组(6/29)20.7%,差异无统计学意义P=0.071。结论氯喹那多-普罗雌烯阴道片在治疗AV中能达到与克林霉素一致的效果,并有减少复发的趋势。

Objective To compare the influence of therapeutic effect and recurrence rate between Clindamycin and Chlorquinaldol-Promestriene on the aerobian vaginitis patients. Methods 98 aerobian vaginitis patients with 15-60 years old who treated in Peking University First Hospital from November, 2009 to April, 2010 were recruited in this study. Patients were divided into two groups randomly. Therapy method in Group A： Chlorquinaldol-Promestriene Vaginal Tablets, one pill per day, by vagina, Qn, 12 days. Group B： Clindamycin, 300mg/day ,by vagina, Qn, 12 days. All patients were under follow-up for 1 mouths. Results ① 7-10 days after the treatment, the total effective rate was 30.6%, was 35.4% （17/48） in group A and 26.0% in group B （13/50）（X^2=1.022, P=0.312）. ② 30 days after the treatment, the recurrent rate of Group A was 5.7%（2/35） and 20.7% （6/29） in Group B （P=0.071）. The symptoms , signs and therapeutic effect showed no significant difference between the two groups. Conclusion Chlorquinaldol-Promestriene Vaginal Tablets has the same therapeutic effect as Clindamycin, and has the tendency of reducing the rate of recurrence.