低频经颅磁刺激对儿童抑郁障碍患者认知功能及生活能力的影响

Effects of low-frequency repetitivetranscranial magnetic stimulation on cognitive function and life ability of children with depressive disorder

目的探讨低频经颅磁刺激对儿童抑郁障碍患者认知功能及生活能力的影响。方法将60例儿童抑郁障碍患者分为2组,每组30例。对照组采用帕罗西汀治疗;实验组采用低频经颅磁刺激治疗,对比2组汉密尔顿抑郁量表(HAMD评分)、简明精神状态量表(MMSE评分)、巴塞尔指数(Barthwl指数)、儿童睡眠习惯问卷(ASHQ评分)、副反应量表(TESS评分)变化及不良反应发生情况。结果 2组疗效等级资料差异无统计学意义(P>0.05),具有可比性。实验组总有效率(93.33%)高于对照组(83.33%),差异无统计学意义(χ~2=1.455,P>0.05)。2组治疗后HAMD评分、ASHQ评分显著降低,MMSE评分、Barthwl指数显著升高(P<0.05);实验组治疗后HAMD评分、ASHQ评分显著降低,MMSE评分、Barthwl指数改善程度显著优于对照组,差异有统计学意义(t=6.451、2.306、6.319、8.819,P<0.05);实验组TESS评分(2.19±0.65)显著低于对照组(3.81±1.27),差异有统计学意义(t=6.219,P<0.05)。实验组不良反应发生率(16.67%)显著低于对照组(43.33%),差异有统计学意义(χ2=3.889,P<0.05)。结论低频经颅磁刺激能显著提高儿童抑郁障碍患者认知功能及生活能力,且不良反应发生率低。

Objective To investigate the effects of low-frequency repetitive transcranial magnetic stimulation on the cognitive function and life ability of children with depressive disorder. Methods A total number of 60 children with depression were divided into two groups with 30 cases in each group. The control group treated with Paroxetine,while the experimental group received transcranial magnetic stimulation therapy. The incidence of adverse reactions and the score of HAMD,MMSE,Barthwl index,ASHQ and TESS were compared between the two groups. Results The grade data of the two groups were similar and the difference was not statistically significant（ P〉 0. 05）. The total efficiency of the experimental group was 93. 33%,which was higher than 83. 33% of the control group,the difference was not statistically significant（ χ2= 1. 455,P 〉0. 05）. After the treatment,the HAMD score and ASHQ score of the two groups were significantly decreased,and the MMSE score and Barthwl index were significantly increased（ P 〈0. 05）. The HAMD score and ASHQ score of the experimental group were significantly lower than those of the control group after the treatment,the MMSE score and Barthwl index improved significantly,the difference was statistically significant（ t = 6. 451,2. 306,6. 319,8. 819,all P 〈0. 05）. The TESS score（ 2. 19 ± 0. 65） in the experimental group was significantly lower than that in the control group（ 3. 81 ± 1. 27）,there was a significant difference（ t = 6. 219,P 〈0. 05）. The incidence of adverse reactions in the experimental group（ 16. 67%） was significantly lower than the control group（ 43. 33%）,there was a significant difference（ χ2= 3. 889,P 〈0. 05）. Conclusion The low frequency transcranial magnetic stimulation in children with depressive disorder can significantly improve the cognitive function and life ability,and the low incidence of adverse reactions.