血小板与肿瘤远处转移关系研究进展

Research progress of the relationship between platelets and distant metastasis of malignant tumor

远处转移是恶性肿瘤重要的特征之一，也是严重恶化患者疗效和预后的主要因素。研究发现肿瘤远处转移的机制较多，如上皮间质转化、肿瘤干细胞学说、肿瘤相关巨噬细胞等。既往研究还发现，血小板可能在肿瘤远处转移过程中发挥了重要作用。本文对近年来血小板与肿瘤远处转移关系进行综述。

Distant metastasis is one of the most important characteristics of malignant tumor, and it is also the vital factor which leads to the worse prognosis. Many studies have shown that a few mechanisms are related to the distant metastasis of malignancies, for example, the epithelial mesenchymal transition （EMT）, cancer stem cell theory, tumor-associated macrophages （TAM）. In recent decades, several clinic studies indicated that platelets maybe improve distant metastasis of malignancies. This paper reviews the research progress of the relationship between platelets and distant metastasis of malignancies.